SCHEMBL6375248

SCHEMBL6375248

Nc1cccc(F)c1OC(F)F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 2/20 0.45
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.35
CRHBP P24387 1/20 0.35
CRHR2 Q13324 1/20 0.35
ALDH1A1 P00352 2/20 0.35
SLC6A2 P23975 5/20 0.33
SLC6A4 P31645 3/20 0.33
SLC6A3 Q01959 2/20 0.33
KMT2A Q03164 1/20 0.33
CYP3A4 P08684 3/20 0.32
TSHR P16473 2/20 0.32
HPGD P15428 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
SCN5A Q14524 1/20 0.32
KCNH2 Q12809 1/20 0.31
PIK3CA P42336 1/20 0.31
ALOX15 P16050 1/20 0.31
CASP1 P29466 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7775162 0.84 SCN9A (0.40) SCN9AALDH1A1SLC6A2SLC6A4SLC6A3
SCHEMBL20505832 0.82 SLC6A4 (0.36) SCN9AKDM4EMAPTCRHBPCRHR2
SCHEMBL29402339 0.78 TSHR (0.43) SCN9AALDH1A1SLC6A2SLC6A4SLC6A3
SCHEMBL5699178 0.78 SCN9A (0.33) SCN9AKDM4EMAPTCRHBPCRHR2
SCHEMBL22366611 0.78 TSHR (0.43) SCN9AALDH1A1SLC6A2SLC6A4SLC6A3
SCHEMBL30079497 0.78 SCN9A (0.33) SCN9AKDM4EMAPTCRHBPCRHR2
SCHEMBL30695904 0.75 SCN9A (0.36) SCN9AKDM4EMAPTCRHBPCRHR2
SCHEMBL23043168 0.75 SCN9A (0.36) SCN9AALDH1A1SLC6A2SLC6A4SLC6A3
SCHEMBL900045 0.75 SCN9A (0.42) SCN9AALDH1A1SLC6A2SLC6A4SLC6A3
SCHEMBL900047 0.75 ACHE (0.44) SCN9ASLC6A2SLC6A4CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3958865-B1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES BAYER AG (DE) 2025-12-10 EP disclosed
US-20240101576-A1 HETEROCYCLIC INHIBITORS OF EGFR AND/OR HER2, FOR USE IN THE TREATMENT OF CANCER ANTARES THERAPEUTICS, INC. 2024-03-28 US disclosed
US-20230364070-A1 PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER ANTARES THERAPEUTICS, INC. 2023-11-16 US disclosed
US-20230364070-A1 PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER ANTARES THERAPEUTICS, INC. 2023-11-16 US disclosed
US-20230364070-A1 PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER ANTARES THERAPEUTICS, INC. 2023-11-16 US disclosed
CN-116997549-A Pyrrolo [3,2-C ] pyridin-4-one derivatives for the treatment of cancer 蝎子疗法股份有限公司 2023-11-03 CN disclosed
CN-116981667-A Heterocyclic inhibitors of EGFR and/or HER2 for cancer treatment 蝎子疗法股份有限公司 2023-10-31 CN disclosed
EP-4225445-A2 HETEROCYCLIC INHIBITORS OF EGFR AND/OR HER2, FOR USE IN THE TREATMENT OF CANCER Scorpion Therapeutics, Inc. (US) 2023-08-16 EP disclosed
EP-4217070-A1 PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER Scorpion Therapeutics, Inc. (US) 2023-08-02 EP disclosed
WO-2022076831-A2 METHODS FOR TREATING CANCER SCORPION THERAPEUTICS, INC. (US) 2022-04-14 WO disclosed
WO-2022072634-A1 BICYCLIC COMPOUNDS FOR USE IN THE TREATMENT CANCER SCORPION THERAPEUTICS, INC. (US) 2022-04-07 WO disclosed
WO-2022066734-A1 PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER SCORPION THERAPEUTICS, INC. (US) 2022-03-31 WO disclosed
EP-3958865-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES Bayer Aktiengesellschaft (DE) 2022-03-02 EP disclosed
WO-2020216774-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2020-10-29 WO disclosed
EP-3700904-A1 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES Bayer AG (DE) 2020-09-02 EP disclosed
EP-1031555-B1 DIFLUOROMETHOXYBENZENE DERIVATIVES AND THEIR USE AS INTERMEDIATES IHARA CHEMICAL IND CO (JP) 2005-04-13 EP disclosed
EP-0878194-A1 REMEDIES OR PREVENTIVES FOR AIDS SANKYO COMPANY LIMITED (JP) 1998-11-18 EP disclosed
US-5688791-A COMPOUNDS FOR TREATMENNT OF VIRAL DISEASES SUCH AS AIDS UBE INDUSTRIES, LTD. (JP) 1997-11-18 US disclosed
US-5519016-A Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent UBE INDUSTRIES, LTD. (JP) 1996-05-21 US disclosed
EP-0572259-A1 Aminoquinolone derivatives as anti-HIV agents UBE INDUSTRIES, LTD. (JP) 1993-12-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230364070-A1 PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER ERBB2, EGFR, ERBB3 SCN9A 4319/4885KDM4E 3981/4885MAPT 1075/4885
US-20240101576-A1 HETEROCYCLIC INHIBITORS OF EGFR AND/OR HER2, FOR USE IN THE TREATMENT OF CANCER ERBB2, EGFR, ERBB3 SCN9A 3882/4885KDM4E 4216/4885MAPT 1090/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.