Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 20/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.72 |
| ▸ | MLNR | O43193 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | DRD1 | P21728 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23660870 | 0.96 | ESR1 (0.68) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL22904939 | 0.93 | ESR1 (0.65) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL24948898 | 0.91 | ESR1 (0.63) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL25079140 | 0.91 | ESR1 (0.64) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL23660869 | 0.91 | ESR1 (0.72) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL26158855 | 0.91 | ESR1 (0.63) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL27570464 | 0.90 | ESR1 (0.62) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL26510970 | 0.90 | ESR1 (0.64) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL22904947 | 0.88 | ESR1 (0.64) | ESR1ESR2MLNRABCB11NR3C1 | |
| SCHEMBL15344637 | 0.88 | ESR1 (0.82) | ESR1ESR2MLNRABCB11NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104311468-A | Bazedoxifene impurity synthesis method | AVENTIS PHARMA HAINAN CO LTD | 2015-01-28 | — | — | CN | claimed |
| WO-2018182205-A1 | STABILIZED PHARMACEUTICAL COMPOSITION CONTAINING BAZEDOXIFENE ACETATE | 한미약품 주식회사 | 2018-10-04 | — | — | WO | disclosed |
| US-20120253038-A1 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | SANDOZ AG (CH) | 2012-10-04 | — | — | US | disclosed |
| US-20120253038-A1 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | SANDOZ AG (CH) | 2012-10-04 | — | — | US | disclosed |
| US-20120253038-A1 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | SANDOZ AG (CH) | 2012-10-04 | — | — | US | disclosed |
| EP-2311805-B1 | New polymorphic form of bazedoxifene acetate | ZENTIVA KS (CZ) | 2012-05-09 | — | — | EP | disclosed |
| EP-2419406-A1 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | Sandoz AG (CH) | 2012-02-22 | — | — | EP | disclosed |
| US-8034807-B2 | Salts of bazedoxifene | ZENTIVA K.S. (CZ) | 2011-10-11 | — | — | US | disclosed |
| US-8034807-B2 | Salts of bazedoxifene | ZENTIVA K.S. (CZ) | 2011-10-11 | — | — | US | disclosed |
| US-8034807-B2 | Salts of bazedoxifene | ZENTIVA K.S. (CZ) | 2011-10-11 | — | — | US | disclosed |
| EP-2311805-A1 | New polymorphic form of bazedoxifene acetate | Zentiva, K.S. (CZ) | 2011-04-20 | — | — | EP | disclosed |
| EP-2185510-B1 | NEW SALTS OF BAZEDOXIFENE | ZENTIVA KS (CZ) | 2011-04-06 | — | — | EP | disclosed |
| WO-2010118997-A1 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | SANDOZ AG (CH) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010118997-A1 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | SANDOZ AG (CH) | 2010-10-21 | — | — | WO | disclosed |
| US-20100240888-A1 | SALTS OF BAZEDOXIFENE | ZENTIVA K.S. (CZ) | 2010-09-23 | — | — | US | disclosed |
| US-20100240888-A1 | SALTS OF BAZEDOXIFENE | ZENTIVA K.S. (CZ) | 2010-09-23 | — | — | US | disclosed |
| US-20100240888-A1 | SALTS OF BAZEDOXIFENE | ZENTIVA K.S. (CZ) | 2010-09-23 | — | — | US | disclosed |
| EP-2185510-A2 | NEW SALTS OF BAZEDOXIFENE | Zentiva, K.S. (CZ) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009012734-A2 | NEW SALTS OF BAZEDOXIFENE | ZENTIVA A.S. (CZ) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009012734-A2 | NEW SALTS OF BAZEDOXIFENE | ZENTIVA A.S. (CZ) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240888-A1 | SALTS OF BAZEDOXIFENE | CYP19A1, SHBG, NR5A1 | ESR1 4/4885ESR2 8/4885MLNR 1707/4885 |
| US-20120253038-A1 | PROCESSES FOR THE SYNTHESIS OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | CYP19A1, HSD17B11, CYP2F1 | ESR1 4/4885ESR2 20/4885MLNR 1875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.