Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 8/20 | 0.57 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.57 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605221 | 0.91 | CXCR2 (0.60) | CXCR2CXCR1CX3CR1EPHX1ALDH1A1 | |
| SCHEMBL4607210 | 0.86 | CXCR2 (0.63) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL6444067 | 0.81 | CXCR2 (0.54) | CXCR2CXCR1CX3CR1CA2 | |
| SCHEMBL4605886 | 0.80 | CXCR2 (0.62) | CXCR2CXCR1CX3CR1MAPTCA2 | |
| SCHEMBL4604578 | 0.79 | HTT (0.56) | CXCR2CXCR1CX3CR1ALDH1A1HTT | |
| SCHEMBL4588234 | 0.78 | CXCR2 (0.59) | CXCR2CXCR1CX3CR1HTT | |
| SCHEMBL4604026 | 0.78 | CXCR2 (0.59) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL4604688 | 0.78 | CXCR2 (0.56) | CXCR2CXCR1CX3CR1CA2 | |
| SCHEMBL4357568 | 0.77 | EPHX1 (0.58) | CXCR2EPHX2MAPTEPHX1ALDH1A1 | |
| SCHEMBL4603360 | 0.77 | CXCR2 (0.58) | CXCR2CXCR1CX3CR1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265603-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-28 | — | — | EP | claimed |
| EP-1265603-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | claimed |
| WO-2001068570-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | claimed |
| EP-1265603-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-28 | — | — | EP | disclosed |
| EP-1265603-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001068570-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |