Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 4/20 | 0.62 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 9/20 | 0.60 |
| ▸ | CA1 | P00915 | 8/20 | 0.60 |
| ▸ | CA12 | O43570 | 7/20 | 0.60 |
| ▸ | CA9 | Q16790 | 7/20 | 0.60 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129953 | 0.88 | CXCR2 (0.65) | CXCR2CXCR1CA2CA1CA12 | |
| SCHEMBL4605221 | 0.83 | CXCR2 (0.60) | CXCR2CXCR1CA2CA1CA12 | |
| SCHEMBL4587524 | 0.80 | CXCR2 (0.74) | CXCR2CXCR1CA2CA1CA12 | |
| SCHEMBL4607210 | 0.80 | CXCR2 (0.63) | CXCR2CXCR1CX3CR1 | |
| SCHEMBL6375481 | 0.80 | CXCR2 (0.57) | CXCR2CXCR1CA2CX3CR1MAPT | |
| SCHEMBL4586744 | 0.79 | CXCR2 (0.81) | CXCR2CXCR1CA2CA1CA12 | |
| SCHEMBL4360010 | 0.79 | SMN1; SMN2 (0.64) | CA2CA1CA12CA9SMN1; SMN2 | |
| SCHEMBL4586814 | 0.78 | CXCR2 (0.64) | CXCR2CXCR1CA2CA1CA12 | |
| SCHEMBL6129954 | 0.77 | CXCR2 (0.60) | CXCR2CXCR1CA2CA1CA12 | |
| SCHEMBL4588234 | 0.77 | CXCR2 (0.59) | CXCR2CXCR1CX3CR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265603-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-28 | — | — | EP | claimed |
| EP-1274415-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-07 | — | — | EP | claimed |
| US-6767922-B2 | ADMINISTERING N-(3-AMINOSULFONYL-2-HYDROXYPHENYL)-UREA DERIVATIVES; TREATMENT OF RESPIRATORY AND NERVOUS SYSTEM DISORDERS; ARTHRITIS, ASTHMA; VIRICIDES | SMITHKLINE BEECHAM CORPORATION | 2004-07-27 | — | — | US | claimed |
| US-20030065170-A1 | Il-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2003-04-03 | — | — | US | claimed |
| US-20030065188-A1 | Il-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2003-04-03 | — | — | US | claimed |
| EP-1274415-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2003-01-15 | — | — | EP | claimed |
| EP-1265603-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | claimed |
| WO-2001068569-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | claimed |
| WO-2001068570-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | claimed |
| EP-1265603-B1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1265603-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-28 | — | — | EP | disclosed |
| EP-1274415-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| US-6767922-B2 | ADMINISTERING N-(3-AMINOSULFONYL-2-HYDROXYPHENYL)-UREA DERIVATIVES; TREATMENT OF RESPIRATORY AND NERVOUS SYSTEM DISORDERS; ARTHRITIS, ASTHMA; VIRICIDES | SMITHKLINE BEECHAM CORPORATION | 2004-07-27 | — | — | US | disclosed |
| US-20030065170-A1 | Il-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2003-04-03 | — | — | US | disclosed |
| US-20030065188-A1 | Il-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2003-04-03 | — | — | US | disclosed |
| EP-1274415-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2003-01-15 | — | — | EP | disclosed |
| EP-1265603-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001068569-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |
| WO-2001068570-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065170-A1 | Il-8 receptor antagonists | CXCL8, CCR8, IL1RN | CXCR2 9/4885CXCR1 13/4885CA2 3402/4885 |
| US-20030065188-A1 | Il-8 receptor antagonists | CXCL8, CCR8, IL1RN | CXCR2 9/4885CXCR1 13/4885CA2 3402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.