Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 6/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64172 | 0.89 | KCNH2 (0.36) | ALDH1A1KDM4EMMP13KCNH2CYP2C9 | |
| SCHEMBL62641 | 0.85 | MMP13 (0.31) | MMP13KCNH2CYP2C9 | |
| SCHEMBL64418 | 0.84 | GLA (0.39) | ALDH1A1MMP13KCNH2CYP2C9NAMPT | |
| SCHEMBL51547 | 0.81 | KCNH2 (0.43) | ALDH1A1MMP13KCNH2CYP2C9 | |
| SCHEMBL64242 | 0.81 | MMP13 (0.39) | ALDH1A1KDM4EMMP13KCNH2CYP2C9 | |
| SCHEMBL62611 | 0.80 | KCNH2 (0.38) | ALDH1A1KDM4EMMP13KCNH2CYP2C9 | |
| SCHEMBL64434 | 0.80 | MMP13 (0.38) | ALDH1A1KDM4EMMP13KCNH2CYP2C9 | |
| SCHEMBL62623 | 0.80 | KCNH2 (0.41) | ALDH1A1KDM4EMMP13KCNH2CYP2C9 | |
| SCHEMBL64237 | 0.80 | MMP13 (0.40) | MMP13KCNH2CYP2C9 | |
| SCHEMBL62607 | 0.79 | KCNH2 (0.42) | ALDH1A1KDM4EMMP13KCNH2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129398-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129398-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090253677-A1 | HIV Integrase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-10-08 | — | — | US | disclosed |
| US-20090253677-A1 | HIV Integrase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-10-08 | — | — | US | disclosed |
| WO-2009117540-A1 | BRIDGED HETEROCYCLES AS HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253677-A1 | HIV Integrase Inhibitors | DNTT, POLB, UNG | ALDH1A1 539/4885KDM4E 1609/4885MMP13 4137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.