Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.49 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 12/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383290 | 0.94 | DYRK3 (0.51) | PIM1PIM3BRSK1AURKBCLK4 | |
| SCHEMBL6378805 | 0.91 | PIM1 (0.52) | PIM1PIM3BRSK1AURKBCLK4 | |
| SCHEMBL6380062 | 0.89 | PARP1 (0.44) | PARP1DHODHHPSEMMP2MMP9 | |
| SCHEMBL6385466 | 0.87 | PIM1 (0.47) | PIM1PIM3BRSK1AURKBCLK4 | |
| SCHEMBL6384304 | 0.86 | PARP1 (0.45) | PARP1DHODHHPSEMMP2MMP9 | |
| SCHEMBL6384729 | 0.85 | HPSE (0.53) | PIM1PIM3BRSK1AURKBCLK4 | |
| SCHEMBL6585497 | 0.84 | PARP1 (0.45) | PIM1PIM3BRSK1AURKBCLK4 | |
| SCHEMBL6381528 | 0.82 | PARP1 (0.58) | PIM1PIM3BRSK1AURKBCLK4 | |
| SCHEMBL6441691 | 0.81 | PIM1 (0.51) | PIM1PIM3BRSK1AURKBCLK4 | |
| SCHEMBL6579124 | 0.80 | MAP4K4 (0.75) | PIM1PIM3BRSK1AURKBCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131301-B1 | 2-PHENYLBENZIMIDAZOLES AND 2-PHENYLINDOLES, AND PRODUCTION AND USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2005-08-24 | — | — | EP | disclosed |