Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 16/20 | 0.50 |
| ▸ | DHODH | Q02127 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585214 | 0.88 | AURKB (0.54) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL7162295 | 0.86 | PIM1 (0.69) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6384304 | 0.86 | PARP1 (0.45) | PARP1DHODHHPSE | |
| SCHEMBL6385741 | 0.84 | PARP1 (0.60) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6587474 | 0.84 | AURKB (0.54) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6380062 | 0.84 | PARP1 (0.44) | PARP1DHODHHPSE | |
| SCHEMBL6382346 | 0.83 | PARP1 (0.60) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6585672 | 0.83 | AURKB (0.54) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6587042 | 0.83 | AURKB (0.75) | PIM1PIM3AURKBMKNK2FLT3 | |
| SCHEMBL6383290 | 0.82 | DYRK3 (0.51) | PIM1PIM3AURKBMKNK2BRSK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131301-B1 | 2-PHENYLBENZIMIDAZOLES AND 2-PHENYLINDOLES, AND PRODUCTION AND USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2005-08-24 | — | — | EP | disclosed |