Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 5/20 | 0.49 |
| ▸ | GJB2 | P29033 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FGF1 | P05230 | 3/20 | 0.38 |
| ▸ | FGF2 | P09038 | 3/20 | 0.38 |
| ▸ | VEGFA | P15692 | 3/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6380615 | 0.88 | TNF (0.60) | TNFGBA1GJB2MAPK1TACR1 | |
| SCHEMBL28296339 | 0.87 | GBA1 (0.51) | TNFGBA1GJB2MAPK1FGF1 | |
| SCHEMBL13760997 | 0.86 | GJB2 (0.47) | TNFGBA1GJB2MAPK1FGF1 | |
| SCHEMBL6380947 | 0.85 | SSTR5 (0.52) | TNFTACR1 | |
| SCHEMBL6380820 | 0.85 | TNF (0.56) | TNFGBA1GJB2MAPK1TACR1 | |
| SCHEMBL8686417 | 0.83 | GBA1 (0.53) | TNFGBA1GJB2MAPK1 | |
| SCHEMBL8686677 | 0.83 | GBA1 (0.53) | TNFGBA1GJB2MAPK1 | |
| SCHEMBL8691523 | 0.83 | GBA1 (0.53) | TNFGBA1GJB2MAPK1 | |
| SCHEMBL8686418 | 0.83 | GBA1 (0.53) | TNFGBA1GJB2MAPK1 | |
| SCHEMBL19277314 | 0.82 | GJB2 (0.48) | TNFGBA1GJB2FGF1FGF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001961-B1 | SUBSTITUTED TETRAHYDROPYRANE DERIVATIVES AND METHOD FOR PRODUCING SAME | AVENTIS PHARMA GMBH (DE) | 2005-01-26 | — | — | EP | disclosed |
| US-6756489-B1 | PROTECTED MONOSACCHARIDES HAVING AN ALLYL PROTECTING GROUP, A SILANE-PROTECTED HYDROXY GROUP AND A CARBOXY OR AMIDE CONTAINING PROTECTIVE GROUP; EASILY MADE BY COMBINATORIAL CHEMISTRY; APPLICATIONS TO AUTOIMMUNE AND CANCER | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-06-29 | — | — | US | disclosed |