Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.48 |
| ▸ | EGFR | P00533 | 6/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384206 | 0.96 | SRC (0.49) | SRCEGFRERBB2FLT1FGFR1 | |
| SCHEMBL6382267 | 0.84 | SRC (0.58) | SRCEGFRERBB2 | |
| SCHEMBL6381989 | 0.84 | SRC (0.68) | SRCEGFRERBB2FLT1FGFR1 | |
| SCHEMBL6382264 | 0.83 | EGFR (0.57) | SRCEGFRERBB2 | |
| SCHEMBL6382681 | 0.82 | SRC (0.62) | SRCEGFRERBB2 | |
| SCHEMBL6386007 | 0.80 | SRC (0.47) | SRCEGFRERBB2STK4 | |
| SCHEMBL6381636 | 0.80 | SRC (0.67) | SRCEGFRERBB2 | |
| SCHEMBL6997301 | 0.79 | SRC (0.58) | SRCEGFRERBB2 | |
| SCHEMBL6384845 | 0.78 | SRC (0.61) | SRCEGFRERBB2 | |
| SCHEMBL6381846 | 0.77 | SRC (0.57) | SRCEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263503-B1 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | WYETH CORP (US) | 2005-11-02 | — | — | EP | claimed |
| EP-0973746-B1 | SUBSTITUTED 3-CYANO QUINOLINES | WYETH CORP (US) | 2003-09-24 | — | — | EP | claimed |