Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 5/20 | 0.43 |
| ▸ | TLR4 | O00206 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GJB2 | P29033 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | FGF1 | P05230 | 1/20 | 0.32 |
| ▸ | FGF2 | P09038 | 1/20 | 0.32 |
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6380656 | 0.85 | TNF (0.46) | TNFGBA1MAPK1GJB2 | |
| SCHEMBL6384903 | 0.82 | TNF (0.55) | TNFGBA1TLR4MAPK1GJB2 | |
| SCHEMBL6383996 | 0.78 | TNF (0.37) | TNFGBA1GJB2 | |
| SCHEMBL6380615 | 0.76 | TNF (0.60) | TNFGBA1MAPK1GJB2 | |
| SCHEMBL6380648 | 0.75 | TNF (0.50) | TNFGBA1MAPK1GJB2FGF1 | |
| SCHEMBL6382250 | 0.74 | SLC6A2 (0.45) | GJB2 | |
| SCHEMBL28274960 | 0.74 | MAPK1 (0.56) | TNFGBA1MAPK1GJB2CA1 | |
| SCHEMBL28276208 | 0.74 | MAPK1 (0.56) | TNFGBA1MAPK1GJB2CA1 | |
| SCHEMBL24943350 | 0.73 | GBA1 (0.36) | TNFGBA1MAPK1GJB2FGF1 | |
| SCHEMBL6380820 | 0.72 | TNF (0.56) | TNFGBA1MAPK1GJB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001961-B1 | SUBSTITUTED TETRAHYDROPYRANE DERIVATIVES AND METHOD FOR PRODUCING SAME | AVENTIS PHARMA GMBH (DE) | 2005-01-26 | — | — | EP | disclosed |
| US-6756489-B1 | PROTECTED MONOSACCHARIDES HAVING AN ALLYL PROTECTING GROUP, A SILANE-PROTECTED HYDROXY GROUP AND A CARBOXY OR AMIDE CONTAINING PROTECTIVE GROUP; EASILY MADE BY COMBINATORIAL CHEMISTRY; APPLICATIONS TO AUTOIMMUNE AND CANCER | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-06-29 | — | — | US | disclosed |