Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 14/20 | 0.62 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.54 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.54 |
| ▸ | CPA3 | P15088 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL107884 | 0.97 | FOLH1 (0.65) | FOLH1GRM3NAALAD2 | |
| SCHEMBL108166 | 0.84 | FOLH1 (0.76) | FOLH1GRM3NAALAD2 | |
| SCHEMBL29060942 | 0.81 | FOLH1 (0.73) | FOLH1GRM3NAALAD2 | |
| SCHEMBL27996973 | 0.81 | FOLH1 (0.73) | FOLH1GRM3NAALAD2 | |
| SCHEMBL13726298 | 0.81 | FOLH1 (0.73) | FOLH1GRM3NAALAD2 | |
| SCHEMBL24533833 | 0.81 | FOLH1 (0.53) | FOLH1 | |
| SCHEMBL928641 | 0.80 | FOLH1 (0.64) | FOLH1GRM3NAALAD2 | |
| SCHEMBL15679634 | 0.78 | FOLH1 (0.48) | FOLH1GRM3NAALAD2 | |
| SCHEMBL28555785 | 0.78 | FOLH1 (0.43) | FOLH1GRM3NAALAD2 | |
| SCHEMBL27739702 | 0.78 | ALOX15 (0.54) | FOLH1GRM3NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3744830-B1 | METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES | GENOMATICA INC (US) | 2023-11-22 | — | — | EP | disclosed |
| EP-3744830-A1 | METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES | Genomatica, Inc. (US) | 2020-12-02 | — | — | EP | disclosed |
| US-10689673-B2 | Bioconversion process for producing nylon-7, nylon-7,7 and polyesters | INVISTA NORTH AMERICA S.A.R.L. (US) | 2020-06-23 | — | — | US | disclosed |
| EP-3087174-B1 | METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES | GENOMATICA INC (US) | 2020-05-13 | — | — | EP | disclosed |
| US-10597684-B2 | Methods and organisms with increased carbon flux efficiencies | GENOMATICA, INC. (US) | 2020-03-24 | — | — | US | disclosed |
| US-10577634-B2 | Bioconversion process for producing nylon-7, nylon-7,7 and polyesters | INVISTA NORTH AMERICA S.A.R.L. (US) | 2020-03-03 | — | — | US | disclosed |
| US-20170298396-A1 | BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS | INV NYLON CHEMICALS AMERICAS, LLC | 2017-10-19 | — | — | US | disclosed |
| US-9650653-B2 | Bioconversion process for producing nylon-7, nylon-7,7 and polyesters | INVISTA NORTH AMERICA S.A.R.L. (US) | 2017-05-16 | — | — | US | disclosed |
| US-20160326553-A1 | METHODS AND ORGANISMS WITH INCREASED CARBON FLUX EFFICIENCIES | GENOMATICA, INC. (US) | 2016-11-10 | — | — | US | disclosed |
| US-20150337275-A1 | BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS | INVISTA TECHNOLOGIES S.A.R.L. (CH) | 2015-11-26 | — | — | US | disclosed |
| US-20150240226-A1 | NUCLEIC ACIDS AND PROTEINS AND METHODS FOR MAKING AND USING THEM | BP CORP NORTH AMERICA INC (US) | 2015-08-27 | — | — | US | disclosed |
| US-8962800-B2 | Nucleic acids and proteins and methods for making and using them | BP CORPORATION NORTH AMERICA INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-20140242655-A1 | Bioconversion Process for Producing Nylon-7, Nylon-7, 7 and Polyesters | INVISTA TECHNOLOGIES S.A R.L. (CH) | 2014-08-28 | — | — | US | disclosed |
| US-20120266329-A1 | Nucleic Acids and Proteins and Methods for Making and Using Them | BP CORPORATION NORTH AMERICA INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-8119385-B2 | Nucleic acids and proteins and methods for making and using them | BP CORPORATION NORTH AMERICA INC. (US) | 2012-02-21 | — | — | US | disclosed |
| US-20110296543-A1 | NUCLEIC ACIDS AND PROTEINS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF CALIFORNIA (US) | 2011-12-01 | — | — | US | disclosed |
| US-20100011456-A1 | Nucleic Acids and Proteins and Methods for Making and Using Them | VERENIUM CORPORATION (US) | 2010-01-14 | — | — | US | disclosed |
| EP-1765418-A4 | METHOD FOR ENHANCING PRODUCTION OF ISOPRENOID COMPOUNDS | UNIV CALIFORNIA (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1765418-A2 | METHOD FOR ENHANCING PRODUCTION OF ISOPRENOID COMPOUNDS | The Regents of the University of California (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006085899-A2 | METHOD FOR ENHANCING PRODUCTION OF ISOPRENOID COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150240226-A1 | NUCLEIC ACIDS AND PROTEINS AND METHODS FOR MAKING AND USING THEM | POLN, POLM, POLI | FOLH1 637/4885GRM3 3262/4885NAALAD2 1691/4885 |
| US-20120266329-A1 | Nucleic Acids and Proteins and Methods for Making and Using Them | POLN, POLM, POLI | FOLH1 637/4885GRM3 3262/4885NAALAD2 1691/4885 |
| US-20100011456-A1 | Nucleic Acids and Proteins and Methods for Making and Using Them | POLN, POLM, POLI | FOLH1 637/4885GRM3 3262/4885NAALAD2 1691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.