Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 11/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.55 |
| ▸ | RAF1 | P04049 | 3/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.55 |
| ▸ | STK4 | Q13043 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6386795 | 0.87 | PDE4B (0.58) | PDE4BEGFRERBB2RAF1MAP2K1 | |
| SCHEMBL6382153 | 0.85 | EGFR (0.50) | EGFRERBB2RAF1MAP2K1STK4 | |
| SCHEMBL6379765 | 0.84 | EGFR (0.57) | PDE4BEGFRERBB2GAK | |
| SCHEMBL5888336 | 0.83 | MAP2K1 (0.52) | EGFRERBB2RAF1MAP2K1STK4 | |
| SCHEMBL6383853 | 0.83 | PDE4B (0.60) | PDE4BEGFRERBB2RAF1MAP2K1 | |
| SCHEMBL6384067 | 0.83 | EGFR (0.58) | EGFRERBB2STK4GAKSRC | |
| SCHEMBL6384102 | 0.83 | EGFR (0.58) | EGFRERBB2GAK | |
| SCHEMBL6383946 | 0.83 | EGFR (0.61) | EGFRERBB2GAK | |
| SCHEMBL6381724 | 0.83 | EGFR (0.47) | EGFRERBB2RAF1MAP2K1GAK | |
| SCHEMBL6383850 | 0.82 | EGFR (0.61) | EGFRERBB2RAF1MAP2K1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263503-B1 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | WYETH CORP (US) | 2005-11-02 | — | — | EP | claimed |
| EP-0973746-B1 | SUBSTITUTED 3-CYANO QUINOLINES | WYETH CORP (US) | 2003-09-24 | — | — | EP | claimed |