Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 6/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | USP14 | P54578 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26814105 | 0.92 | KCNA3 (0.56) | KCNA3CTSKDRD2DRD3CCR5 | |
| SCHEMBL23421609 | 0.87 | KCNA3 (0.55) | KCNA3CTSKDRD2DRD3CCR5 | |
| SCHEMBL3460701 | 0.87 | KCNA3 (0.55) | KCNA3CTSKDRD2DRD3CCR5 | |
| SCHEMBL4419007 | 0.87 | KCNA3 (0.55) | KCNA3CTSKDRD2DRD3CCR5 | |
| SCHEMBL9092293 | 0.86 | KCNA3 (0.54) | KCNA3CTSKDRD2DRD3CCR5 | |
| SCHEMBL24690239 | 0.86 | KCNA3 (0.54) | KCNA3CTSKDRD2DRD3CCR5 | |
| SCHEMBL30893341 | 0.85 | KCNA3 (0.53) | KCNA3CTSKDRD2DRD3CCR5 | |
| SCHEMBL28840007 | 0.85 | KCNA3 (0.53) | KCNA3CTSKDRD2DRD3CCR5 | |
| SCHEMBL26814329 | 0.85 | KCNA3 (0.53) | KCNA3CTSKDRD2DRD3CCR5 | |
| SCHEMBL26813557 | 0.85 | KCNA3 (0.53) | KCNA3CTSKDRD2DRD3CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | disclosed |
| US-6200989-B1 | ADMINISTERING AS UROKINASE PLASMINOGEN ACTIVATOR ANTAGONISTS, ANTITUMOR AND ANTIMETASTASIS AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-13 | — | — | US | disclosed |