Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 15/20 | 0.49 |
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382258 | 0.90 | EGFR (0.47) | MAP3K8EGFRMAPKAPK2SRCMAPK14 | |
| SCHEMBL6383964 | 0.90 | MAP3K8 (0.47) | MAP3K8EGFRMAPKAPK2SRCMAPK14 | |
| SCHEMBL6383708 | 0.87 | EGFR (0.59) | MAP3K8EGFRMAPKAPK2SRCMAPK14 | |
| SCHEMBL6383946 | 0.84 | EGFR (0.61) | EGFRERBB2 | |
| SCHEMBL6384102 | 0.84 | EGFR (0.58) | MAP3K8EGFRERBB2 | |
| SCHEMBL6386289 | 0.84 | EGFR (0.52) | EGFRERBB2 | |
| SCHEMBL6382269 | 0.83 | MAP3K8 (0.46) | MAP3K8EGFRMAPKAPK2SRCMAPK14 | |
| SCHEMBL6384067 | 0.82 | EGFR (0.58) | MAP3K8EGFRSRCERBB2 | |
| SCHEMBL6379765 | 0.81 | EGFR (0.57) | MAP3K8EGFRERBB2 | |
| SCHEMBL6382251 | 0.81 | EGFR (0.54) | MAP3K8EGFRSRCERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263503-B1 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | WYETH CORP (US) | 2005-11-02 | — | — | EP | claimed |
| EP-0973746-B1 | SUBSTITUTED 3-CYANO QUINOLINES | WYETH CORP (US) | 2003-09-24 | — | — | EP | claimed |