SCHEMBL6384685

SCHEMBL6384685

CC(O)C(Cl)N1CCOCC1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.38
KCNA5 P22460 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
PKM P14618 1/20 0.35
ALDH1A1 P00352 4/20 0.35
KMT2A Q03164 3/20 0.35
MAPT P10636 2/20 0.35
LMNA P02545 1/20 0.35
HPGD P15428 1/20 0.35
RAB9A P51151 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
KDM4E B2RXH2 1/20 0.33
CYP3A4 P08684 1/20 0.33
TSHR P16473 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSD17B10 Q99714 1/20 0.32
MEN1 O00255 2/20 0.32
GAA P10253 1/20 0.31
KCNH2 Q12809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6549666 0.98 ALDH1A1 (0.37) USP2KCNA5SMN1; SMN2PKMALDH1A1
SCHEMBL8026943 0.80 SMN1; SMN2 (0.37) SMN1; SMN2KMT2AMEN1
SCHEMBL4359607 0.78 USP2 (0.39) USP2KCNA5SMN1; SMN2PKMALDH1A1
SCHEMBL134990 0.77
SCHEMBL1777128 0.77
SCHEMBL23515492 0.77
Hydrochloric Acid SCHEMBL11607003 0.75 USP2 (0.41) USP2KCNA5SMN1; SMN2PKMALDH1A1
SCHEMBL29105480 0.75 USP2 (0.41) USP2KCNA5SMN1; SMN2PKMALDH1A1
SCHEMBL9694114 0.75 USP2 (0.46) USP2KCNA5SMN1; SMN2PKMALDH1A1
Hydrochloric Acid SCHEMBL10975982 0.75 ALDH1A1 (0.36) USP2KCNA5SMN1; SMN2PKMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599207-A2 TREATMENT OF EXCESSIVE OSTEOLYISIS WITH INDOLINONE COMPOUNDS Sugen, Inc. (US) 2005-11-30 EP disclosed
WO-2004075775-A2 TREATMENT OF EXCESSIVE OSTEOLYISIS WITH INDOLINONE COMPOUNDS SUGEN, INC. (US) 2004-09-10 WO disclosed
EP-1370554-A1 3-(4-AMIDOPYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 2003-12-17 EP disclosed
WO-2002066463-A1 3-(4-AMIDOPYRROL-2-YLMETHLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 2002-08-29 WO disclosed