Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.47 |
| ▸ | KDR | P35968 | 10/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384853 | 0.91 | RAF1 (0.58) | RAF1KDRFLT1BRAFHDAC3 | |
| SCHEMBL5446241 | 0.85 | RAF1 (0.54) | RAF1KDRFLT1BRAFHDAC3 | |
| SCHEMBL6388341 | 0.85 | RAF1 (0.51) | RAF1KDRFLT1BRAFHDAC3 | |
| SCHEMBL5437656 | 0.82 | RAF1 (0.58) | RAF1KDRFLT1BRAFHDAC3 | |
| SCHEMBL3406605 | 0.81 | RAF1 (0.65) | RAF1KDRFLT1BRAFHDAC3 | |
| SCHEMBL3413370 | 0.81 | RAF1 (0.68) | RAF1KDRFLT1BRAFHDAC3 | |
| SCHEMBL5447334 | 0.79 | RET (0.49) | RAF1KDRFLT1BRAFPDGFRB | |
| SCHEMBL14447685 | 0.77 | RAF1 (0.50) | RAF1KDRFLT1BRAFPDGFRB | |
| SCHEMBL3543215 | 0.76 | RAF1 (0.67) | RAF1KDRFLT1BRAFHDAC3 | |
| SCHEMBL5337325 | 0.75 | RET (0.63) | RAF1KDRFLT1BRAFPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603879-A2 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS | Bayer Pharmaceuticals Corporation (US) | 2005-12-14 | — | — | EP | claimed |
| WO-2004078128-A2 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-09-16 | — | — | WO | claimed |