Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.51 |
| ▸ | KDR | P35968 | 10/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MUSK | O15146 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | PDE6D | O43924 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | CDK14 | O94921 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6388343 | 0.90 | RAF1 (0.63) | RAF1KDRFLT1BRAFMEN1 | |
| SCHEMBL6384852 | 0.85 | RAF1 (0.47) | RAF1KDRFLT1BRAFMEN1 | |
| SCHEMBL3410987 | 0.82 | RAF1 (0.72) | RAF1KDRFLT1BRAFMEN1 | |
| SCHEMBL3413370 | 0.81 | RAF1 (0.68) | RAF1KDRFLT1BRAFMEN1 | |
| SCHEMBL13547755 | 0.76 | RAF1 (0.66) | RAF1KDRFLT1BRAFHDAC3 | |
| SCHEMBL6384853 | 0.75 | RAF1 (0.58) | RAF1KDRFLT1BRAFMEN1 | |
| SCHEMBL3543215 | 0.75 | RAF1 (0.67) | RAF1KDRFLT1BRAFPDGFRB | |
| SCHEMBL3539177 | 0.74 | KDR (0.54) | RAF1KDRFLT1BRAFMEN1 | |
| SCHEMBL5424304 | 0.73 | RAF1 (0.52) | RAF1KDRFLT1BRAFMEN1 | |
| SCHEMBL545637 | 0.73 | KDR (0.52) | RAF1KDRFLT1BRAFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603879-A2 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS | Bayer Pharmaceuticals Corporation (US) | 2005-12-14 | — | — | EP | claimed |
| WO-2004078128-A2 | SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-09-16 | — | — | WO | claimed |