Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6385334 | 1.00 | CCNA2 (0.49) | CCNA2CDK2CCNA1PTPN1TDP1 | |
| SCHEMBL6386332 | 0.92 | CCNA2 (0.48) | CCNA2CDK2CCNA1PTPN1TDP1 | |
| SCHEMBL6386329 | 0.92 | CCNA2 (0.48) | CCNA2CDK2CCNA1PTPN1TDP1 | |
| SCHEMBL6389855 | 0.90 | CCNA2 (0.52) | CCNA2CDK2CCNA1MAPK8MAPK9 | |
| SCHEMBL6389857 | 0.90 | CCNA2 (0.52) | CCNA2CDK2CCNA1MAPK8MAPK9 | |
| SCHEMBL6388842 | 0.90 | CCNA2 (0.55) | CCNA2CDK2CCNA1MAPK8MAPK9 | |
| SCHEMBL6388838 | 0.90 | CCNA2 (0.55) | CCNA2CDK2CCNA1MAPK8MAPK9 | |
| SCHEMBL6389201 | 0.89 | NPY5R (0.56) | CCNA2CDK2CCNA1MAPK8MAPK9 | |
| SCHEMBL6389206 | 0.89 | NPY5R (0.56) | CCNA2CDK2CCNA1MAPK8MAPK9 | |
| SCHEMBL6391298 | 0.86 | CCNA2 (0.49) | CCNA2CDK2CCNA1L3MBTL1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209297-A1 | Pyrazole derivatives | PFIZER INC | 2005-09-22 | — | — | US | claimed |
| US-20020103185-A1 | Pyrazole derivatives | PFIZER PRODUCTS INC. | 2002-08-01 | — | — | US | claimed |
| US-20050209297-A1 | Pyrazole derivatives | PFIZER INC | 2005-09-22 | — | — | US | disclosed |
| US-20020103185-A1 | Pyrazole derivatives | PFIZER PRODUCTS INC. | 2002-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209297-A1 | Pyrazole derivatives | CDK1, CDK3, CDK5 | CCNA2 482/4885CDK2 7/4885CCNA1 175/4885 |
| US-20020103185-A1 | Pyrazole derivatives | CDK1, CDK5, CDK3 | CCNA2 558/4885CDK2 5/4885CCNA1 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.