SCHEMBL6385644

O=C1NC(=O)C(=Cc2ccc3ncnc(N4CCC(OC(=O)C5CCN(c6ncnc7ccc(C=C8SC(=O)NC8=O)cc67)CC5)CC4)c3c2)S1.O=C1NC(=O)C(=Cc2ccc3ncnc(N4CCCC(C(=O)O)C4)c3c2)S1.O=C1NC(=O)C(=Cc2ccc3ncnc(N4CCCC4C(=O)O)c3c2)S1

nearest known ligand 0.41

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	DYRK1A	Q13627	2/20	0.41

▸	PIK3CD	O00329	1/20	0.38

▸	HPGD	P15428	15/20	0.38

▸	ALDH1A1	P00352	1/20	0.37

▸	CYP1A2	P05177	1/20	0.37

▸	CLK4	Q9HAZ1	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4636083	0.97	DYRK1A (0.39)	DYRK1APIK3CDHPGDALDH1A1CYP1A2
SCHEMBL2882765	0.86	DYRK1A (0.52)	DYRK1APIK3CDHPGD
SCHEMBL2882769	0.86	DYRK1A (0.52)	DYRK1APIK3CDHPGD
SCHEMBL12975503	0.86	DYRK1A (0.52)	DYRK1APIK3CDHPGD
SCHEMBL6254891	0.85	MAPK1 (0.49)	DYRK1AHPGDALDH1A1CYP1A2CLK4
SCHEMBL2881919	0.84	PIK3CD (0.47)	DYRK1APIK3CDHPGD
SCHEMBL12975468	0.84	PIK3CD (0.47)	DYRK1APIK3CDHPGD
SCHEMBL2881916	0.84	PIK3CD (0.47)	DYRK1APIK3CDHPGD
SCHEMBL12975464	0.81	PIK3CD (0.51)	DYRK1APIK3CDHPGDALDH1A1CYP1A2
SCHEMBL2877240	0.81	PIK3CD (0.51)	DYRK1APIK3CDHPGDALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1549644-A1	AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES	Applied Research Systems ARS Holding N.V. (AN)	2005-07-06	—	—	EP	claimed
WO-2004007491-A1	AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES	APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN)	2004-01-22	—	—	WO	claimed