⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1828548 | 0.73 | — | — | |
| SCHEMBL555976 | 0.66 | — | — | |
| SCHEMBL18044433 | 0.66 | — | — | |
| SCHEMBL293883 | 0.65 | — | — | |
| SCHEMBL28242131 | 0.65 | — | — | |
| SCHEMBL24674673 | 0.65 | — | — | |
| SCHEMBL6387753 | 0.65 | — | — | |
| SCHEMBL21360181 | 0.60 | — | — | |
| SCHEMBL6015504 | 0.58 | HIF1A (0.43) | — | |
| SCHEMBL3048131 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209217-A1 | 3-Mercaptopyrrolidines as farnesyl protein transferase inhibitors | BOYLE FRANCIS T | 2005-09-22 | — | — | US | disclosed |
| US-6946468-B1 | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors | ZENECA LIMITED (GB) | 2005-09-20 | — | — | US | disclosed |
| EP-0923545-A1 | 3-MERCAPTOPYRROLIDINES AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998007692-A1 | 3-MERCAPTOPYRROLIDINES AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 1998-02-26 | — | — | WO | disclosed |