Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (+)-Tranylcypromine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 9/20 | 1.00 |
| ▸ | MAOA known ✓ | P21397 | 7/20 | 1.00 |
| ▸ | KDM1A | O60341 | 14/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.95 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.95 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.95 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.95 |
| ▸ | HTR1A | P08908 | 1/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.95 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.95 |
| ▸ | HTR2C | P28335 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+)-Tranylcypromine SCHEMBL4380284 | 1.00 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA | |
| (+)-Tranylcypromine SCHEMBL56350 | 1.00 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA | |
| (+)-Tranylcypromine SCHEMBL145687 | 1.00 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA | |
| (+)-Tranylcypromine SCHEMBL56351 | 1.00 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA | |
| (+)-Tranylcypromine SCHEMBL56352 | 1.00 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA | |
| (+)-Tranylcypromine SCHEMBL7759844 | 1.00 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA | |
| (+)-Tranylcypromine SCHEMBL13785162 | 0.97 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA | |
| (+)-Tranylcypromine SCHEMBL3406205 | 0.97 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA | |
| (+)-Tranylcypromine SCHEMBL40651 | 0.97 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA | |
| (+)-Tranylcypromine SCHEMBL1649712 | 0.97 | KDM1A (1.00) | KDM1AMAOBMAOATAAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861524-B2 | Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents | AVENTIS PHARMACEUTICALS INC. (US) | 2005-03-01 | — | — | US | claimed |