Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.50 |
| ▸ | AURKA | O14965 | 5/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.48 |
| ▸ | LCK | P06239 | 4/20 | 0.48 |
| ▸ | LYN | P07948 | 4/20 | 0.48 |
| ▸ | RET | P07949 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.48 |
| ▸ | FLT1 | P17948 | 4/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.48 |
| ▸ | AXL | P30530 | 4/20 | 0.48 |
| ▸ | FLT3 | P36888 | 4/20 | 0.48 |
| ▸ | FRK | P42685 | 4/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.48 |
| ▸ | CLK2 | P49760 | 4/20 | 0.48 |
| ▸ | BLK | P51451 | 4/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6390212 | 0.79 | KDR (0.56) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL3526174 | 0.79 | KDR (0.74) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL6385546 | 0.77 | KDR (0.52) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL27636493 | 0.74 | KDR (0.63) | KDRAURKBROCK2RPS6KA5MAP4K4 | |
| SCHEMBL3609309 | 0.74 | KDR (0.56) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL30883193 | 0.73 | TSHR (0.57) | — | |
| SCHEMBL27661176 | 0.72 | KDR (0.53) | KDRAURKAAURKBROCK2LCK | |
| SCHEMBL16879411 | 0.72 | TSHR (0.53) | — | |
| SCHEMBL6387113 | 0.71 | EPHB4 (0.48) | KDRAURKAAURKBROCK2RPS6KA5 | |
| SCHEMBL27661163 | 0.70 | KDR (0.54) | KDRAURKAAURKBROCK2RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020619-A1 | Thienopyridine kinase inhibitors | ABBOTT LABORATORIES | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020619-A1 | Thienopyridine kinase inhibitors | ABL1, MAP4K2, MAP4K5 | KDR 511/4885AURKA 293/4885AURKB 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.