SCHEMBL6394248

SCHEMBL6394248

[CH2]NC(=O)Nc1ccc(OC)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.78
NPC1 O15118 6/20 0.78
SMN1; SMN2 Q16637 5/20 0.78
MAPT P10636 4/20 0.64
MEN1 O00255 2/20 0.64
KMT2A Q03164 2/20 0.64
KDM4E B2RXH2 2/20 0.64
SAE1 Q9UBE0 1/20 0.64
UBA2 Q9UBT2 1/20 0.64
TP53 P04637 3/20 0.62
ESR2 Q92731 1/20 0.62
NOX1 Q9Y5S8 1/20 0.62
TGM2 P21980 1/20 0.61
TSHR P16473 1/20 0.60
ALOX15 P16050 1/20 0.59
POLB P06746 4/20 0.58
PKM P14618 1/20 0.58
CA12 O43570 1/20 0.58
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11092496 0.88 RAB9A (1.00) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL6324843 0.82 RAB9A (0.81) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL17628550 0.82 RAB9A (0.88) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL11875380 0.82 RAB9A (0.81) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL6388672 0.81 MAPT (0.73) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL31325106 0.81 RAB9A (0.78) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL1897292 0.81 RAB9A (0.85) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL6827864 0.81 RAB9A (0.78) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL11106394 0.81 RAB9A (0.85) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL8361583 0.81 RAB9A (0.85) RAB9ANPC1SMN1; SMN2MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6844366-B2 Sulfonamide hydroxamates SYNTEX (U.S.A.) LLC (US) 2005-01-18 US claimed