Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.68 |
| ▸ | MET | P08581 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 9/20 | 0.51 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | FYN | P06241 | 3/20 | 0.47 |
| ▸ | YES1 | P07947 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 6/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6396110 | 1.00 | PRKDC (0.68) | PRKDCMETSRCKDRFGFR1 | |
| SCHEMBL2115334 | 0.85 | MET (0.70) | PRKDCMETSRCKDRFGFR1 | |
| SCHEMBL2115337 | 0.85 | MET (0.70) | PRKDCMETSRCKDRFGFR1 | |
| SCHEMBL6796402 | 0.81 | PRKDC (1.00) | PRKDCSRCKDRFGFR1LCK | |
| SCHEMBL29467770 | 0.81 | PRKDC (1.00) | PRKDCSRCKDRFGFR1LCK | |
| SCHEMBL6796396 | 0.81 | PRKDC (1.00) | PRKDCSRCKDRFGFR1LCK | |
| SCHEMBL29399522 | 0.74 | MET (0.70) | METSRCKDRFGFR1MEN1 | |
| SCHEMBL3798305 | 0.73 | AURKA (0.64) | PRKDCMETSRCKDRFGFR1 | |
| SCHEMBL3798297 | 0.73 | AURKA (0.64) | PRKDCMETSRCKDRFGFR1 | |
| SCHEMBL143738 | 0.71 | KDR (0.69) | METSRCKDRFGFR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878733-B1 | Formulations for pharmaceutical agents ionizable as free acids or free bases | SUGEN, INC. (US) | 2005-04-12 | — | — | US | disclosed |