Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.75 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | POLB | P06746 | 4/20 | 0.71 |
| ▸ | GFER | P55789 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ACLY | P53396 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284552 | 0.84 | POLB (0.63) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL5244715 | 0.81 | NPC1 (0.55) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL5247775 | 0.81 | POLB (0.72) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL5244667 | 0.79 | KMT2A (0.70) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL6395928 | 0.77 | KMT2A (0.70) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL6393006 | 0.76 | POLB (0.68) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL5245166 | 0.76 | KMT2A (0.74) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL6397592 | 0.76 | KMT2A (0.78) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL5244832 | 0.75 | POLB (0.61) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL16002834 | 0.75 | POLB (0.63) | ALDH1A1KMT2AMAPTMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | claimed |
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282818-A1 | Ubiquitin ligase inhibitors | NEDD4, TRAF6, XIAP | ALDH1A1 2627/4885KMT2A 1303/4885MAPT 1681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.