TRAF6

TNF receptor-associated factor 6 · Q9Y4K3 · TRAF6 on Sugi Atlas →

12 patent compounds predicted against TRAF6, 6 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL11105186 SCHEMBL11105186 0.49 1/20
SCHEMBL7507915 SCHEMBL7507915 0.49 1/20
SCHEMBL10165440 SCHEMBL10165440 0.44 1/20
SCHEMBL10547065 SCHEMBL10547065 0.43 1/20
SCHEMBL16932349 SCHEMBL16932349 0.42 1/20
SCHEMBL30214703 SCHEMBL30214703 0.42 1/20

Clinical trials — most relevant to TRAF6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Predictability Studies on the Efficacy of TNF-α Inhibitors in Chinese RA From Real World PHASE4UNKNOWN
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer PHASE4UNKNOWN
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
TNFSF11 Inhibition and Fertility: a Prospective Study PHASE2COMPLETED
Tocilizumab in the Treatment of Refractory Polymyositis and Dermatomyositis PHASE2COMPLETED
Etanercept (Enbrel) to Treat Pain and Swelling After Third Molar Extraction PHASE2COMPLETED
Denosumab for the Treatment of Adult LCH PHASE2COMPLETED
Denosumab for High Risk SMM and SLiM CRAB Positive, Early Myeloma Patients PHASE2COMPLETED
Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis PHASE2COMPLETED
Study of BCMA/CD70 CAR-T Therapy for Refractory cSLE PHASE1RECRUITING
Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial PHASE1UNKNOWN
MicroRNAs and Cytokines in Peri-Implantitis Tissue nanUNKNOWN
Role of NFKBIA and PTPN22 Genes Polymorphism in Acute Rejection Susceptibility After Living Donor Liver Transplantation in Egyptian Patients. nanCOMPLETED
Novel Biomarkers in Inflammatory Bowel Disease nanCOMPLETED
Functional Implications of TNF nanCOMPLETED
Genetic Variation in TRAF3IP2 (rs13190932) nanRECRUITING
Adipocytokines in Endometrial Cancer nanCOMPLETED
Effect of Alcohol Consumption on Markers of Inflammation nanCOMPLETED
Clinical Study of Desuzumab in the Treatment of Knee Osteoarthritis nanRECRUITING
Effect of Smoking on Periodontal Therapy in Periodontitis nanCOMPLETED
DC-STAMP & TRAF3: Regulators of Osteoclastogenesis and Biomarkers in PsA nanCOMPLETED
Contact Cast Versus Posterior Slab as Offloading Modality for Charcot Neuroarthropathy nanRECRUITING
Peri-implantitis and MMP-8 nanCOMPLETED
Serum Interleukin - 17A in Juvenile Idiopathic Arthritis nanUNKNOWN
DC-STAMP: Regulators of Osteoclastogenesis and Response Marker in PsA nanCOMPLETED
Cardioprotective Effect of Melatonin Versus Vitamin D in Breast Cancer Patients Receiving Doxorubicin nanNOT_YET_RECRUITING
Diagnosis of Inflammatory Bowel Disease nanNOT_YET_RECRUITING
The Neuroprotective Effect of Dexmedetomidine Preserving Brain Functional Connectivity in Elderly Patients nanCOMPLETED
Periduroscopy: Correlation Between the Outcome of Procedure and Histological-biochemical, Neuroinflammation and Genetic Factors. nanUNKNOWN
RORC Genetic Polymorphism of Rheumatoid Arthritis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TRAF6 binder may also engage these)

ProteinNameSimilarity
P70196 1.000 P70196 →
B6CJY4 1.000 B6CJY4 →
Q3ZCC3 1.000 Q3ZCC3 →
Q28DL4 1.000 Q28DL4 →
B6CJY5 1.000 B6CJY5 →
A7XUJ6 1.000 A7XUJ6 →
B5DF45 1.000 B5DF45 →
Q6DJN2 0.998 Q6DJN2 →
Q3MV19 0.989 Q3MV19 →
Q6IWL4 0.989 Q6IWL4 →
P70191 0.979 P70191 →
Q13114 0.979 Q13114 →
P39429 0.977 P39429 →
Q9UJV3 0.975 Q9UJV3 →
Q9QUS6 0.975 Q9QUS6 →
P82457 0.975 P82457 →
O00463 0.974 O00463 →
Q9BUZ4 0.974 Q9BUZ4 →
Q60803 0.973 Q60803 →
Q3KPU8 0.973 Q3KPU8 →
O70583 0.973 O70583 →
Q61382 0.972 Q61382 →
Q80WG7 0.972 Q80WG7 →
O15344 0.970 O15344 →
TRAF2 TNF receptor-associated factor 2 0.970 landscape →
Q91ZY8 0.969 Q91ZY8 →
Q9C026 0.968 Q9C026 →
Q29RQ5 0.967 Q29RQ5 →
Q6J1I7 0.967 Q6J1I7 →
Q1L721 0.967 Q1L721 →