SCHEMBL6397462

SCHEMBL6397462

CC(=O)NCC1CN(c2ccc(C3CCN(C(=O)CO)CC3)cc2)C(=O)O1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
F10 P00742 11/20 0.53
MAOA P21397 4/20 0.52
MAOB P27338 2/20 0.52
LMNA P02545 1/20 0.52
PTGS1 P23219 1/20 0.52
CALML3 P27482 1/20 0.52
SDHA P31040 1/20 0.52
ABCB11 O95342 1/20 0.46
ITGB3 P05106 2/20 0.45
PRSS1 P07477 2/20 0.45
PRSS2 P07478 2/20 0.45
ITGA2B P08514 2/20 0.45
PRSS3 P35030 2/20 0.45
F2 P00734 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6397455 1.00 F10 (0.53) F10MAOAMAOBLMNAPTGS1
SCHEMBL10162513 0.95 F10 (0.52) F10MAOAMAOBLMNAPTGS1
SCHEMBL10162624 0.88 F10 (0.55) F10MAOAMAOBLMNAPTGS1
SCHEMBL14197150 0.87 MAOA (0.52) F10MAOAMAOBLMNAPTGS1
SCHEMBL4883478 0.87 MAOA (0.52) F10MAOAMAOBLMNAPTGS1
SCHEMBL10162818 0.86 F10 (0.53) F10MAOAMAOBLMNAPTGS1
SCHEMBL6704404 0.86 F10 (0.49) F10MAOBF2
SCHEMBL6399367 0.86 F10 (0.46) F10MAOAMAOBLMNAPTGS1
SCHEMBL6399364 0.86 F10 (0.46) F10MAOAMAOBLMNAPTGS1
SCHEMBL6403105 0.85 MAOA (0.62) F10MAOAMAOBLMNAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0856002-B1 PHENYLOXAZOLIDINONES HAVING A C-C BOND TO 4-8 MEMBERED HETEROCYCLIC RINGS UPJOHN CO (US) 2001-10-24 EP claimed
CN-1072222-C Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings UPJOHN CO (US) 2001-10-03 CN claimed
CN-1197457-A Phenyloxazolidinones having a C-C bond to a 4-8 membered heterocyclic ring UPJOHN CO (US) 1998-10-28 CN claimed
US-20050054683-A1 Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings HUTCHINSON DOUGLAS K (US) 2005-03-10 US disclosed
US-6358942-B1 MICROBIOCIDES AND BACTERICIDES FOR TREATING GRAMPOSITIVE, BACTEROIDES, CLOSTRIDIUM, MYCOBACTERIUM, STAPHYLOCOCCUS AND STREPTOCOCCUS INFECTIONS PHARMACIA & UPJOHN COMPANY 2002-03-19 US disclosed
US-6313307-B1 DEBLOCKING, DEPROTECTING; CATALYTIC HYDROGENATION, ALKYLATION; PREPARING MICROBIOCIDES AGAINST STAPHYLOCOCCUS, STREPTOCOCCUS, MYCOBACTERIUM, AND CLOSTRIDIUM PHARMACIA & UPJOHN COMPANY 2001-11-06 US disclosed
EP-0856002-B1 PHENYLOXAZOLIDINONES HAVING A C-C BOND TO 4-8 MEMBERED HETEROCYCLIC RINGS UPJOHN CO (US) 2001-10-24 EP disclosed
CN-1072222-C Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings UPJOHN CO (US) 2001-10-03 CN disclosed
US-6166056-A Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings PHARMACIA (US) 2000-12-26 US disclosed
US-6051716-A ANTIMICROBIAL AGENTS PHARMACIA & UPJOHN, INC. (US) 2000-04-18 US disclosed
US-6043266-A MICROBIOCIDES TREATING GRAM-POSITIVE BACTERIA INFECTIONS AND PERSONS WITH AIDS PHARMACIA & UPJOHN COMPANY (US) 2000-03-28 US disclosed
US-5968962-A ANTIMICROBIAL AGENTS; EFFECTIVE AGAINST GRAMPOSITIVE BACTERIA PHARMACIA & UPJOHN COMPANY (US) 1999-10-19 US disclosed
CN-1197457-A Phenyloxazolidinones having a C-C bond to a 4-8 membered heterocyclic ring UPJOHN CO (US) 1998-10-28 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050054683-A1 Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings CBR1, NCOR1, RCOR1 F10 4219/4885MAOA 2948/4885MAOB 2473/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.