4-Chloro Chalcone

4-Chloro Chalcone

SCHEMBL6399394

CCCCCCl.O=C(C=Cc1ccc(Cl)cc1)c1ccccc1

nearest known ligand 0.71

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.71
CYP1B1 Q16678 2/20 0.62
MAPT P10636 3/20 0.58
RAB9A P51151 2/20 0.58
KMT2A Q03164 2/20 0.58
NPC1 O15118 1/20 0.58
MAOA P21397 2/20 0.56
CYP3A4 P08684 3/20 0.55
ALDH1A1 P00352 1/20 0.55
HPGD P15428 1/20 0.55
BCHE P06276 2/20 0.54
PLIN1 O60240 1/20 0.54
LMNA P02545 1/20 0.54
TNFRSF1A P19438 1/20 0.54
ACHE P22303 1/20 0.54
RECQL P46063 1/20 0.54
PLIN5 Q00G26 1/20 0.54
ABHD5 Q8WTS1 1/20 0.54
CXCL12 P48061 1/20 0.54
NFKB1 P19838 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Chloro Chalcone SCHEMBL6399398 1.00 MAOB (0.71) MAOBCYP1B1MAPTRAB9AKMT2A
4-Chloro Chalcone SCHEMBL28825168 0.92 MAOB (0.79) MAOBCYP1B1MAPTRAB9AKMT2A
Chalcone SCHEMBL6392677 0.92 BCHE (0.65) MAOBCYP1B1MAPTRAB9AKMT2A
Chalcone SCHEMBL6392672 0.92 BCHE (0.65) MAOBCYP1B1MAPTRAB9AKMT2A
SCHEMBL27588183 0.90 MAPT (0.71) MAOBCYP1B1MAPTRAB9AKMT2A
SCHEMBL27606021 0.88 MAOB (0.57) MAOBCYP1B1MAPTRAB9AKMT2A
4-Chloro Chalcone SCHEMBL197311 0.84 MAOB (1.00) MAOBCYP1B1MAPTRAB9AKMT2A
4-Chloro Chalcone SCHEMBL198518 0.84 MAOB (1.00) MAOBCYP1B1MAPTRAB9AKMT2A
4-Chloro Chalcone SCHEMBL197310 0.84 MAOB (1.00) MAOBCYP1B1MAPTRAB9AKMT2A
Acetone SCHEMBL29037569 0.82 KDM4E (0.49) MAOBMAPTRAB9AKMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050014928-A1 Epoxy resin polymer and alignment film materials containing same for liquid crystal display ETERNAL CHEMICAL CO., LTD. (TW) 2005-01-20 US claimed
CN-1548463-A Epoxy resin polymer, preparation method thereof and liquid crystal alignment layer material containing the same 长兴化学工业股份有限公司 2004-11-24 CN claimed
US-6962931-B2 Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors PFIZER INC. (US) 2005-11-08 US disclosed
US-20050014928-A1 Epoxy resin polymer and alignment film materials containing same for liquid crystal display ETERNAL CHEMICAL CO., LTD. (TW) 2005-01-20 US disclosed
CN-1548463-A Epoxy resin polymer, preparation method thereof and liquid crystal alignment layer material containing the same 长兴化学工业股份有限公司 2004-11-24 CN disclosed
US-20030022944-A1 Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors PFIZER INC. 2003-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030022944-A1 Self-emulsifying formulations of cholesteryl ester transfer protein inhibitors CETP, LCAT, LIPA MAOB 2640/4885CYP1B1 1828/4885MAPT 1895/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.