4-Chloro Chalcone

4-Chloro Chalcone

SCHEMBL197311

O=C(C=Cc1ccc(Cl)cc1)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 1.00
CYP1B1 Q16678 2/20 0.86
MAPT P10636 4/20 0.75
LMNA P02545 2/20 0.75
BCHE P06276 2/20 0.75
PLIN1 O60240 1/20 0.75
TNFRSF1A P19438 1/20 0.75
ACHE P22303 1/20 0.75
RECQL P46063 1/20 0.75
PLIN5 Q00G26 1/20 0.75
ABHD5 Q8WTS1 1/20 0.75
CXCL12 P48061 1/20 0.72
CYP3A4 P08684 3/20 0.71
NFKB1 P19838 2/20 0.71
NFKB2 Q00653 2/20 0.71
RELA Q04206 2/20 0.71
HSPD1 P10809 1/20 0.71
PKM P14618 1/20 0.71
RAB9A P51151 1/20 0.71
HSPE1 P61604 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Chloro Chalcone SCHEMBL197310 1.00 MAOB (1.00) MAOBCYP1B1MAPTLMNABCHE
4-Chloro Chalcone SCHEMBL198518 1.00 MAOB (1.00) MAOBCYP1B1MAPTLMNABCHE
SCHEMBL196425 0.93 CYP1B1 (1.00) MAOBCYP1B1MAPTLMNABCHE
SCHEMBL196424 0.93 CYP1B1 (1.00) MAOBCYP1B1MAPTLMNABCHE
SCHEMBL10415521 0.93 CYP1B1 (1.00) MAOBCYP1B1MAPTLMNABCHE
4',4-Dichlorochalcone SCHEMBL659210 0.90 MAOB (0.86) MAOBCYP1B1MAPTTNFRSF1ACXCL12
4',4-Dichlorochalcone SCHEMBL659211 0.90 MAOB (0.86) MAOBCYP1B1MAPTTNFRSF1ACXCL12
SCHEMBL9915665 0.90 CYP1B1 (0.91) MAOBCYP1B1MAPTLMNABCHE
SCHEMBL8431772 0.90 CYP1B1 (0.91) MAOBCYP1B1MAPTLMNABCHE
SCHEMBL657311 0.90 MAOB (0.81) MAOBCYP1B1MAPTLMNABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12576396-B2 Polynorbornene/carbon black-cross-linked three-dimensional network-immobilized copper/gold (PNBI/CB-Cu/Au) nanocatalyst, and preparation method and use thereof Hubei Engineering University (CN) 2026-03-17 US claimed
US-20240261768-A1 POLYNORBORNENE/CARBON BLACK-CROSS-LINKED THREE-DIMENSIONAL NETWORK-IMMOBILIZED COPPER/GOLD (PNBI/CB-Cu/Au) NANOCATALYST, AND PREPARATION METHOD AND USE THEREOF Hubei Engineering University (CN) 2024-08-08 US claimed
CN-117384199-A Preparation of novel organic aluminum hydrogen compound and preparation method of unsaturated alcohol compound catalyzed by novel organic aluminum hydrogen compound 北京理工大学 2024-01-12 CN claimed
CN-113620901-B Crown ether derived chiral 1,1 '-bi-2, 2' -naphthol, preparation method and application thereof 杭州师范大学 2023-02-10 CN claimed
CN-114797976-A Preparation and application of crosslinked norbornene copolymer/carbon black three-dimensional network immobilized bimetallic copper/gold nano catalyst 湖北工程学院 2022-07-29 CN claimed
CN-113620901-A Crown ether derived chiral 1,1 '-bi-2, 2' -naphthol, preparation method and application thereof 杭州师范大学 2021-11-09 CN claimed
US-12576396-B2 Polynorbornene/carbon black-cross-linked three-dimensional network-immobilized copper/gold (PNBI/CB-Cu/Au) nanocatalyst, and preparation method and use thereof Hubei Engineering University (CN) 2026-03-17 US disclosed
US-20250051299-A1 PRODUCTION METHOD FOR FLUOROMETHYL DERIVATIVE DAIKIN INDUSTRIES, LTD. (JP) 2025-02-13 US disclosed
US-12162854-B2 Production method for fluoromethyl derivative DAIKIN INDUSTRIES, LTD. (JP) 2024-12-10 US disclosed
CN-116199597-B Substituted phenyl diazonium salt and application thereof in catalytic preparation of 3-substituted indole compounds 盐城利民农化有限公司 2024-12-03 CN disclosed
US-20240261768-A1 POLYNORBORNENE/CARBON BLACK-CROSS-LINKED THREE-DIMENSIONAL NETWORK-IMMOBILIZED COPPER/GOLD (PNBI/CB-Cu/Au) NANOCATALYST, AND PREPARATION METHOD AND USE THEREOF Hubei Engineering University (CN) 2024-08-08 US disclosed
US-20240174698-A1 MODULAR SYNTHESIS OF 1,2-AZABORINES VIA RING-OPENING BN-ISOSTERE BENZANNULATION THE UNIVERSITY OF CHICAGO 2024-05-30 US disclosed
CN-117843626-A Ketone Kangxian-based triazole analogue, and preparation method and application thereof 宿迁晨阳医药科技有限公司 2024-04-09 CN disclosed
WO-1992001675-A2 SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS RHONE-POULENC RORER S.A. (FR) 1992-02-06 WO disclosed
US-4910303-A Cataltyic reaction using N-alkylbis(2-hydroxyalkyl)amine TEXACO CHEMICAL COMPANY (US) 1990-03-20 US disclosed
US-4439418-A UNSATURATED ARYL KETONE HENKEL KGAA (DE) 1984-03-27 US disclosed
EP-0004624-B1 CHROMANON DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICINES AND GROWTH-PROMOTING AGENTS BAYER AG (DE) 1982-02-24 EP disclosed
US-4261988-A ANTICHOLESTEROL AGENTS USED IN ANIMAL HUSBANDRY BAYER AKTIENGESELLSCHAFT (DE) 1981-04-14 US disclosed
EP-0004624-A2 Chromanon derivatives, process for their preparation, and their use as medicines and growth-promoting agents BAYER AG (DE) 1979-10-17 EP disclosed
US-3989708-A HYPOTENSIVE, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240261768-A1 POLYNORBORNENE/CARBON BLACK-CROSS-LINKED THREE-DIMENSIONAL NETWORK-IMMOBILIZED COPPER/GOLD (PNBI/CB-Cu/Au) NANOCATALYST, AND PREPARATION METHOD AND USE THEREOF AOC3, PNN, RPL23A MAOB 382/4885CYP1B1 351/4885MAPT 1563/4885
US-20240174698-A1 MODULAR SYNTHESIS OF 1,2-AZABORINES VIA RING-OPENING BN-ISOSTERE BENZANNULATION NBAS, DBF4, ALKBH2 MAOB 96/4885CYP1B1 16/4885MAPT 4581/4885
US-12576396-B2 Polynorbornene/carbon black-cross-linked three-dimensional network-immobilized copper/gold (PNBI/CB-Cu/Au) nanocatalyst, and preparation method and use thereof AOC3, PNN, SOD3 MAOB 326/4885CYP1B1 229/4885MAPT 1217/4885
US-12162854-B2 Production method for fluoromethyl derivative AFF1, AFF2, ROS1 MAOB 20/4885CYP1B1 23/4885MAPT 3085/4885
US-20250051299-A1 PRODUCTION METHOD FOR FLUOROMETHYL DERIVATIVE AFF1, AFF2, ROS1 MAOB 20/4885CYP1B1 23/4885MAPT 3085/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.