Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.50 |
| ▸ | IKBKB | O14920 | 3/20 | 0.50 |
| ▸ | RAF1 | P04049 | 3/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.50 |
| ▸ | AKT1 | P31749 | 3/20 | 0.50 |
| ▸ | AKT2 | P31751 | 3/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.50 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.50 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.50 |
| ▸ | NEK1 | Q96PY6 | 3/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.50 |
| ▸ | PRDX1 | Q06830 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28054895 | 0.87 | NPC1 (0.54) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL8889644 | 0.85 | NPC1 (0.52) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| Cyclopentanone SCHEMBL28852100 | 0.79 | NPC1 (0.48) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL6398530 | 0.79 | MAPK1 (0.47) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL6397809 | 0.79 | MAPK1 (0.47) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL6398533 | 0.79 | MAPK1 (0.47) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL12948680 | 0.77 | MAPK1 (0.70) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL6403613 | 0.77 | NPC1 (0.42) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL625689 | 0.76 | MAPK1 (0.58) | MAPK1IKBKBRAF1RPS6KB1AKT1 | |
| SCHEMBL15051734 | 0.75 | MAPK1 (0.53) | MAPK1IKBKBRAF1RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949585-B2 | Cyclooctanone derivatives and cyclodecanone derivative, and use thereof | EISAI CO., LTD. (JP) | 2005-09-27 | — | — | US | disclosed |
| US-20040082805-A1 | Cyclooctanone derivatives and cyclodecanone derivative, and use thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-04-29 | — | — | US | disclosed |
| EP-1375465-A9 | CYCLOOCTANONE DERIVATIVE AND CYCLODECANONE DERIVATIVE, AND USE THEREOF | Eisai Co., Ltd. (JP) | 2004-04-14 | — | — | EP | disclosed |
| EP-1375479-A1 | PYRROLIDINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | Eisai Co., Ltd. (JP) | 2004-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082805-A1 | Cyclooctanone derivatives and cyclodecanone derivative, and use thereof | CCR1, CCL2, CCR5 | MAPK1 1166/4885IKBKB 886/4885RAF1 2109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.