Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 15/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30582823 | 0.87 | TRPM8 (0.83) | TRPM8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2718096 | 0.87 | TRPM8 (0.83) | TRPM8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2719225 | 0.86 | TRPM8 (0.79) | TRPM8GAASMN1; SMN2TP53THRB | |
| SCHEMBL30582810 | 0.86 | TRPM8 (0.79) | TRPM8GAASMN1; SMN2TP53THRB | |
| SCHEMBL6408147 | 0.86 | TRPM8 (0.72) | TRPM8TP53THRB | |
| SCHEMBL2718577 | 0.85 | TRPM8 (0.80) | TRPM8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30582876 | 0.85 | TRPM8 (0.80) | TRPM8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2720202 | 0.85 | TRPM8 (0.80) | TRPM8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30582847 | 0.85 | TRPM8 (0.80) | TRPM8CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17230197 | 0.85 | TRPM8 (0.84) | TRPM8GAASMN1; SMN2TP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061698-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012061698-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-05-10 | — | — | WO | disclosed |