Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 10/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394489 | 0.92 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL6396062 | 0.91 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL6400247 | 0.89 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL6401565 | 0.88 | MAPK13 (0.50) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL6395553 | 0.87 | MAPK14 (0.54) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL6398542 | 0.86 | MAPK13 (0.47) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL6905610 | 0.86 | MAPK13 (0.64) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL6402341 | 0.86 | MAPK13 (0.50) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL7647177 | 0.85 | MAPK13 (0.62) | MAPK13MAPK12MAPK11MAPK14MEN1 | |
| SCHEMBL2198762 | 0.85 | MAPK13 (0.44) | MAPK13MAPK12MAPK11MAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897236-B1 | Aminobenzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS, LTD. (DK) | 2005-05-24 | — | — | US | claimed |
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | claimed |
| US-6897236-B1 | Aminobenzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS, LTD. (DK) | 2005-05-24 | — | — | US | disclosed |
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |