Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 9/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198762 | 0.91 | MAPK13 (0.44) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6394489 | 0.88 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6400902 | 0.88 | MAPK13 (0.55) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6396062 | 0.87 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6398542 | 0.86 | MAPK13 (0.47) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6400247 | 0.85 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL6395887 | 0.85 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6821134 | 0.84 | MAPK13 (0.61) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL1901468 | 0.83 | MAPK13 (0.57) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL6906823 | 0.83 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897236-B1 | Aminobenzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS, LTD. (DK) | 2005-05-24 | — | — | US | disclosed |
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |