Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.59 |
| ▸ | HTR2A | P28223 | 13/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.59 |
| ▸ | DRD2 | P14416 | 10/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6397695 | 0.94 | HTR1A (0.54) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6401306 | 0.94 | HTR1A (0.59) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6399873 | 0.89 | HTR1A (0.54) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL5777922 | 0.84 | HTR1A (0.41) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6399699 | 0.84 | HTR1A (0.61) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6400727 | 0.84 | HTR1A (0.65) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6397700 | 0.83 | HTR1A (0.52) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6402177 | 0.83 | HTR1A (0.57) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6400489 | 0.82 | HTR1A (0.63) | HTR1AHTR2AKCNH2DRD2HTR7 | |
| SCHEMBL6399037 | 0.81 | HTR1A (0.68) | HTR1AHTR2AKCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288376-A1 | Bicyclyl or heterobicyclylmethanesulfonylanimo-substituted N-hydroxyformamides | SMITHKLINE BEECHAM PLC | 2005-12-29 | — | — | US | disclosed |
| US-20050282819-A1 | Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia | GRAHAM JAMES M | 2005-12-22 | — | — | US | disclosed |
| EP-1289980-B1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-20040024066-A1 | Bicyclyl or heterobicyclylmethanesulfonylamino-substituted n-hydroxyformamides | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-02-05 | — | — | US | disclosed |
| EP-1289980-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090100-A1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282819-A1 | Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia | CHRM1, CHRM2, CHRM5 | HTR1A 61/4885HTR2A 195/4885KCNH2 114/4885 |
| US-20050288376-A1 | Bicyclyl or heterobicyclylmethanesulfonylanimo-substituted N-hydroxyformamides | CD22, CD2, NEU3 | HTR1A 924/4885HTR2A 938/4885KCNH2 994/4885 |
| US-20040024066-A1 | Bicyclyl or heterobicyclylmethanesulfonylamino-substituted n-hydroxyformamides | CD22, CD2, NEU3 | HTR1A 525/4885HTR2A 1014/4885KCNH2 1199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.