Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544264 | 1.00 | LMNA (0.43) | LMNAMAPTRXFP1ALDH1A1CYP3A4 | |
| SCHEMBL1543711 | 0.87 | LMNA (0.43) | LMNAMAPTRXFP1ALDH1A1CYP3A4 | |
| SCHEMBL1544079 | 0.85 | LMNA (0.55) | LMNAMAPTALDH1A1CYP3A4TSHR | |
| SCHEMBL1543757 | 0.84 | POLB (0.55) | LMNAMAPTRXFP1ALDH1A1CYP3A4 | |
| SCHEMBL1543530 | 0.84 | LMNA (0.57) | LMNAMAPTALDH1A1CYP3A4TSHR | |
| SCHEMBL1544111 | 0.84 | LMNA (0.47) | LMNAMAPTRXFP1ALDH1A1CYP3A4 | |
| SCHEMBL1544203 | 0.84 | MAPT (0.54) | LMNAMAPTALDH1A1TSHRNPC1 | |
| SCHEMBL1544243 | 0.84 | GRM5 (0.55) | LMNAMAPTALDH1A1TSHRNPC1 | |
| SCHEMBL1543613 | 0.83 | LMNA (0.43) | LMNAMAPTRXFP1ALDH1A1CYP3A4 | |
| SCHEMBL1544093 | 0.83 | CYP3A4 (0.48) | LMNAMAPTRXFP1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529045-A2 | NEW COMPOUNDS | Astra Zeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004014881-A2 | '1,2,4'OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | ASTRA ZENECA AB (SE) | 2004-02-19 | — | — | WO | disclosed |