Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.63 |
| ▸ | FLT3 | P36888 | 3/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.63 |
| ▸ | MET | P08581 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.61 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402191 | 1.00 | KDR (0.63) | KDRPDGFRBFLT3AURKBMET | |
| SCHEMBL6884531 | 0.90 | PDGFRB (0.63) | KDRPDGFRBFLT3AURKBMET | |
| SCHEMBL6884535 | 0.90 | PDGFRB (0.63) | KDRPDGFRBFLT3AURKBMET | |
| SCHEMBL6404789 | 0.90 | PDGFRB (0.63) | KDRPDGFRBFLT3AURKBMET | |
| SCHEMBL6404793 | 0.90 | PDGFRB (0.63) | KDRPDGFRBFLT3AURKBMET | |
| SCHEMBL7011789 | 0.86 | KDR (0.73) | KDRPDGFRBFLT3AURKBMET | |
| SCHEMBL7009163 | 0.85 | KDR (0.59) | KDRPDGFRBFLT3AURKBMET | |
| SCHEMBL6319847 | 0.82 | KDR (0.56) | KDRPDGFRBFLT3AURKBMET | |
| SCHEMBL6319851 | 0.82 | KDR (0.56) | KDRPDGFRBFLT3AURKBMET | |
| SCHEMBL13755251 | 0.82 | KDR (0.78) | KDRPDGFRBFLT3AURKBMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |