Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.63 |
| ▸ | KDR | P35968 | 11/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.63 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | NEK2 | P51955 | 1/20 | 0.52 |
| ▸ | MELK | Q14680 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404793 | 1.00 | PDGFRB (0.63) | PDGFRBKDRFGFR1TLK2FLT3 | |
| SCHEMBL6884531 | 0.91 | PDGFRB (0.63) | PDGFRBKDRFGFR1TLK2FLT3 | |
| SCHEMBL6884535 | 0.91 | PDGFRB (0.63) | PDGFRBKDRFGFR1TLK2FLT3 | |
| SCHEMBL6402191 | 0.90 | KDR (0.63) | PDGFRBKDRFGFR1TLK2FLT3 | |
| SCHEMBL6402187 | 0.90 | KDR (0.63) | PDGFRBKDRFGFR1TLK2FLT3 | |
| SCHEMBL4484347 | 0.89 | KDR (0.57) | PDGFRBKDRFGFR1TLK2FLT3 | |
| SCHEMBL4484343 | 0.89 | KDR (0.57) | PDGFRBKDRFGFR1TLK2FLT3 | |
| SCHEMBL6322106 | 0.87 | PIM1 (0.49) | PDGFRBKDRFGFR1TLK2FLT3 | |
| SCHEMBL13755252 | 0.84 | KDR (0.81) | PDGFRBKDRFGFR1TLK2FLT3 | |
| SCHEMBL13755251 | 0.84 | KDR (0.78) | PDGFRBKDRFGFR1TLK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |