Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 10/20 | 0.67 |
| ▸ | TP53 | P04637 | 7/20 | 0.67 |
| ▸ | LMNA | P02545 | 6/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717391 | 0.88 | TRPM8 (0.84) | TRPM8TP53LMNATHRBTDP1 | |
| SCHEMBL6408512 | 0.87 | TRPM8 (0.79) | TRPM8TP53LMNATHRBTDP1 | |
| SCHEMBL30582855 | 0.87 | TRPM8 (0.67) | TRPM8TP53LMNATHRBTDP1 | |
| SCHEMBL2720222 | 0.87 | TRPM8 (0.67) | TRPM8TP53LMNATHRBTDP1 | |
| SCHEMBL30582804 | 0.87 | TP53 (0.81) | TRPM8TP53LMNATHRBTDP1 | |
| SCHEMBL2719406 | 0.87 | TP53 (0.81) | TRPM8TP53LMNATHRBTDP1 | |
| SCHEMBL2719111 | 0.87 | TP53 (0.88) | TRPM8TP53LMNATHRBTDP1 | |
| SCHEMBL2717186 | 0.87 | TP53 (0.74) | TRPM8TP53LMNATHRBTDP1 | |
| SCHEMBL30582863 | 0.87 | TP53 (0.74) | TRPM8TP53LMNATHRBTDP1 | |
| SCHEMBL30582815 | 0.87 | TP53 (0.88) | TRPM8TP53LMNATHRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061698-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012061698-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2012-05-10 | — | — | WO | disclosed |