SCHEMBL6404437

SCHEMBL6404437

FC(F)Oc1cc[nH]n1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30684960 0.98
Methane SCHEMBL29277164 0.87 TRPV4 (0.38)
SCHEMBL29277162 0.85 TRPV4 (0.37)
SCHEMBL29277150 0.84 TRPV4 (0.30)
SCHEMBL29277208 0.84
SCHEMBL29037056 0.77
SCHEMBL3337826 0.76
SCHEMBL29139233 0.76
SCHEMBL31251435 0.73 LRRK2 (0.33)
SCHEMBL7164470 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117263925-A Synthesis method of pyrifos 湖北泰盛化工有限公司 2023-12-22 CN claimed
CN-117229278-A Synthesis method of trifluoromethyl-bis-isothiazolinone-difluoromethoxy pyrazole compound 宁夏佰斯特医药化工有限公司 2023-12-15 CN claimed
US-20040059128-A1 Method of producing 1-alkyl-3-aryl-5-difluoromethoxy-ih-pyrazoles BASF AKTIENGESELLSCHAFT (DE) 2004-03-25 US claimed
JP-6199806-A None JP disclosed
EP-4678641-A1 QUINOLINONE COMPOUND AND NAPHTHYRIDINONE COMPOUND AND USE THEREOF Shanghai Helioson Pharmaceutical Co., Ltd. (CN) 2026-01-14 EP disclosed
CN-117263925-B Sulfopyrrole (L.) Harf Synthesis method of azole 湖北泰盛化工有限公司 2025-10-31 CN disclosed
US-20250326772-A1 MRGPRX2 ANTAGONISTS, PHARMACEUTICAL COMPOSITION INCLUDING MRGPRX2 ANTAGONIST, AND METHOD OF TREATING MRGPRX2-MEDIATED DISEASE OR DISORDER KYORIN SEIYAKU KK (JP) 2025-10-23 US disclosed
US-20250326773-A1 MRGPRX2 ANTAGONISTS, PHARMACEUTICAL COMPOSITION INCLUDING MRGPRX2 ANTAGONIST, AND METHOD OF TREATING MRGPRX2-MEDIATED DISEASE OR DISORDER KYORIN SEIYAKU KK (JP) 2025-10-23 US disclosed
US-12441726-B2 Compounds and uses thereof FOGHORN THERAPEUTICS, INC. (US) 2025-10-14 US disclosed
US-12258327-B2 5-membered heteroaryl-containing aminopyridine compounds as EGFR inhibitors YUHAN CORPORATION (KR) 2025-03-25 US disclosed
CN-119677738-A Compounds and uses thereof 福宏治疗公司 2025-03-21 CN disclosed
WO-2015095788-A1 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE MERCK SHARP & DOHME CORP. (US) 2015-06-25 WO disclosed
WO-2015095792-A1 CARBAMATE BENZOXAXINE PROPIONIC ACIDS AND ACID DERIVATIVES FOR MODULATION OF RORGAMMA ACTIVITY AND THE TREATMENT OF DISEASE MERCK SHARP & DOHME CORP. (US) 2015-06-25 WO disclosed
WO-2015095788-A1 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE MERCK SHARP & DOHME CORP. (US) 2015-06-25 WO disclosed
WO-2015095792-A1 CARBAMATE BENZOXAXINE PROPIONIC ACIDS AND ACID DERIVATIVES FOR MODULATION OF RORGAMMA ACTIVITY AND THE TREATMENT OF DISEASE MERCK SHARP & DOHME CORP. (US) 2015-06-25 WO disclosed
US-6897322-B2 Method of producing 1-alkyl-3-aryl-5-difluoromethoxy-1H-pyrazoles BASF AKTIENGESELLSCHAFT (DE) 2005-05-24 US disclosed
US-20040059128-A1 Method of producing 1-alkyl-3-aryl-5-difluoromethoxy-ih-pyrazoles BASF AKTIENGESELLSCHAFT (DE) 2004-03-25 US disclosed
US-6545033-B1 GABA receptor inhibitors 3-DIMENSIONAL PHARMACEUTICALS, INC. 2003-04-08 US disclosed
WO-2001025241-A2 FUSED 1-(2,6-DICHLORO-4-TRIFLUOROMETHYLPHENYL)-PYRAZOLES, THE SYNTHESIS THEREOF AND THE USE THEREOF AS PESTICIDES 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 2001-04-12 WO disclosed
JP-H06199806-A DIFLUOROMETHOXYPYRAZOLE DERIVATIVE AND ITS PRODUCTION NIPPON NOHYAKU CO LTD 1994-07-19 JP disclosed