Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 1/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.77 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.76 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.76 |
| ▸ | DRD2 | P14416 | 3/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.73 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.73 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.72 |
| ▸ | PLD2 | O14939 | 1/20 | 0.69 |
| ▸ | HTR7 | P34969 | 1/20 | 0.68 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5984495 | 0.94 | CYP2D6 (0.85) | PLD1CYP2D6CYP2C9CHRM1OPRM1 | |
| SCHEMBL6404859 | 0.93 | CHRM1 (0.88) | PLD1CYP2D6CYP2C9CHRM1OPRM1 | |
| SCHEMBL10311362 | 0.92 | CYP2D6 (0.73) | PLD1CYP2D6CYP2C9CHRM1OPRM1 | |
| SCHEMBL28539041 | 0.92 | CYP2D6 (0.86) | PLD1CYP2D6CYP2C9CHRM1OPRM1 | |
| Bromide SCHEMBL11719960 | 0.91 | CYP2D6 (0.72) | PLD1CYP2D6CYP2C9CHRM1OPRM1 | |
| SCHEMBL5777954 | 0.90 | OPRM1 (0.77) | PLD1CYP2D6CYP2C9CHRM1OPRM1 | |
| SCHEMBL5772590 | 0.90 | CYP2D6 (1.00) | PLD1CYP2D6CYP2C9CHRM1OPRM1 | |
| SCHEMBL7963223 | 0.89 | CYP2D6 (0.77) | PLD1CYP2D6CYP2C9CHRM1OPRM1 | |
| SCHEMBL6406273 | 0.88 | CHRM1 (0.77) | PLD1CYP2D6CYP2C9CHRM1OPRM1 | |
| SCHEMBL5773820 | 0.88 | CHRM1 (0.75) | PLD1CYP2D6CYP2C9CHRM1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130961-A1 | Muscarinic M1 receptor agonists for pain management | ACADIA PHARMACEUTICALS INC. | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130961-A1 | Muscarinic M1 receptor agonists for pain management | CHRM1, CHRM3, CHRM2 | PLD1 712/4885CYP2D6 1240/4885CYP2C9 2182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.