Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTPRC | P08575 | 1/20 | 0.31 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.30 |
| ▸ | WNT3A | P56704 | 2/20 | 0.30 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404629 | 0.82 | CYP2A6 (0.43) | CYP2A6PDE10AMEN1KMT2APTPRC | |
| SCHEMBL6401548 | 0.77 | CYP2A6 (0.45) | CYP2A6PDE10AMEN1KMT2APTPRC | |
| SCHEMBL6406961 | 0.73 | CYP2A6 (0.46) | CYP2A6PDE10ASIGMAR1PTPRCPTPN6 | |
| SCHEMBL6610892 | 0.71 | CYP2A6 (0.41) | CYP2A6PDE10ASIGMAR1MEN1KMT2A | |
| SCHEMBL8186959 | 0.69 | CYP2A6 (0.59) | CYP2A6PDE10ASIGMAR1MEN1KMT2A | |
| SCHEMBL6406160 | 0.69 | CYP2A6 (0.37) | CYP2A6PDE10APTPRCPTPN6PTPN11 | |
| SCHEMBL3816398 | 0.67 | CYP2A6 (0.56) | CYP2A6PDE10ASIGMAR1PTPRCPTPN6 | |
| SCHEMBL6398236 | 0.66 | CYP2A6 (0.51) | CYP2A6PDE10ASIGMAR1MEN1KMT2A | |
| SCHEMBL6608998 | 0.66 | CYP2A6 (0.41) | CYP2A6SIGMAR1MEN1KMT2APTPRC | |
| SCHEMBL6605866 | 0.66 | ALDH1A1 (0.57) | CYP2A6MEN1KMT2ACTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288376-A1 | Bicyclyl or heterobicyclylmethanesulfonylanimo-substituted N-hydroxyformamides | SMITHKLINE BEECHAM PLC | 2005-12-29 | — | — | US | disclosed |
| EP-1289980-B1 | BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-20040024066-A1 | Bicyclyl or heterobicyclylmethanesulfonylamino-substituted n-hydroxyformamides | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288376-A1 | Bicyclyl or heterobicyclylmethanesulfonylanimo-substituted N-hydroxyformamides | CD22, CD2, NEU3 | CYP2A6 486/4885PDE10A 4559/4885SIGMAR1 914/4885 |
| US-20040024066-A1 | Bicyclyl or heterobicyclylmethanesulfonylamino-substituted n-hydroxyformamides | CD22, CD2, NEU3 | CYP2A6 459/4885PDE10A 4613/4885SIGMAR1 809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.