Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.58 |
| ▸ | CTSK | P43235 | 5/20 | 0.58 |
| ▸ | CTSB | P07858 | 2/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269676 | 0.82 | ATM (0.54) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL18928686 | 0.81 | ATM (0.51) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL28921896 | 0.81 | ATM (0.53) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL3803942 | 0.81 | ATM (0.53) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL67020 | 0.78 | ACE (0.79) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL21473784 | 0.78 | ACE (0.79) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL795685 | 0.78 | ACE (0.79) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL7269746 | 0.78 | CTSS (0.70) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL606309 | 0.78 | ACE (0.79) | CTSSCTSKCTSBCTSLATM | |
| SCHEMBL66220 | 0.78 | ACE (0.79) | CTSSCTSKCTSBCTSLATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119389-B2 | Rhodococcus erythropolis strain | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-02-21 | — | — | US | disclosed |
| EP-1893765-B1 | A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2011-11-30 | — | — | EP | disclosed |
| US-20090286303-A1 | PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED) AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2009-11-19 | — | — | US | disclosed |
| US-7582468-B2 | Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-01 | — | — | US | disclosed |
| EP-1893765-A1 | A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF | Brystol-Myers Squibb Company (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006127180-A1 | A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-11-30 | — | — | WO | disclosed |
| US-20060270012-A1 | Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof | BRISTOL-MYERS SQUIBB COMPANY | 2006-11-30 | — | — | US | disclosed |