Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.47 |
| ▸ | CDK4 | P11802 | 8/20 | 0.46 |
| ▸ | CCND1 | P24385 | 8/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.46 |
| ▸ | CDK9 | P50750 | 6/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.46 |
| ▸ | CDK11A | Q9UQ88 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196586 | 0.99 | CDK5 (0.47) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6198767 | 0.98 | CDK5 (0.47) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6197452 | 0.95 | CDK4 (0.47) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6195363 | 0.94 | CDK5 (0.46) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6199472 | 0.94 | CDK4 (0.52) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6195431 | 0.93 | CDK4 (0.46) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6200133 | 0.93 | CDK4 (0.46) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6415897 | 0.93 | CDK4 (0.46) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6200037 | 0.93 | CDK5 (0.47) | CDK5CDK5R1CDK4CCND1CCNT1 | |
| SCHEMBL6408754 | 0.91 | CDK5 (0.44) | CDK5CDK5R1CDK4CCND1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050101595-A1 | N-containing cycloalkyl-substituted amino-thiazole derivatives and pharmaceutical compositions for inhibiting cell proliferation and methods for their use | PFIZER INC. | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101595-A1 | N-containing cycloalkyl-substituted amino-thiazole derivatives and pharmaceutical compositions for inhibiting cell proliferation and methods for their use | CCNI, MKI67, TK1 | CDK5 10/4885CDK5R1 125/4885CDK4 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.