Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 6/20 | 0.45 |
| ▸ | CDK4 | P11802 | 4/20 | 0.45 |
| ▸ | CCND1 | P24385 | 4/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.42 |
| ▸ | CDK11A | Q9UQ88 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198232 | 0.86 | CDK5 (0.48) | ALDH1A1CDK5CDK5R1CDK2CDK4 | |
| SCHEMBL6197281 | 0.83 | CDK4 (0.50) | CDK5CDK5R1CDK2CDK4CCND1 | |
| SCHEMBL6196544 | 0.83 | CDK4 (0.48) | CDK5CDK5R1CDK2CDK4CCND1 | |
| SCHEMBL6198310 | 0.82 | CDK5 (0.54) | CDK5CDK5R1CDK2CDK4CCND1 | |
| SCHEMBL6193981 | 0.81 | CDK5 (0.52) | CDK5CDK5R1CDK2CDK4CCND1 | |
| SCHEMBL3384264 | 0.81 | CDK2 (0.64) | CDK5CDK5R1CDK2CDK4CCND1 | |
| SCHEMBL6199927 | 0.80 | CDK2 (0.46) | CDK5CDK5R1CDK2CDK4CCND1 | |
| SCHEMBL6196520 | 0.80 | CDK5 (0.50) | CDK5CDK5R1CDK2CDK4CCND1 | |
| Hydrochloric Acid SCHEMBL6407582 | 0.80 | CDK2 (0.44) | CDK5CDK5R1CDK2CDK4CCND1 | |
| SCHEMBL6197196 | 0.80 | CDK2 (0.53) | CDK5CDK5R1CDK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050101595-A1 | N-containing cycloalkyl-substituted amino-thiazole derivatives and pharmaceutical compositions for inhibiting cell proliferation and methods for their use | PFIZER INC. | 2005-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101595-A1 | N-containing cycloalkyl-substituted amino-thiazole derivatives and pharmaceutical compositions for inhibiting cell proliferation and methods for their use | CCNI, MKI67, TK1 | ALDH1A1 2277/4885CDK5 10/4885CDK5R1 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.