Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6396408 | 0.94 | MDM2 (0.56) | MDM2NPC1CSNK1DCSNK1A1CSNK1E | |
| SCHEMBL6396411 | 0.94 | MDM2 (0.56) | MDM2NPC1CSNK1DCSNK1A1CSNK1E | |
| SCHEMBL6406388 | 0.87 | ERBB2 (0.52) | MDM2NPC1CSNK1DCSNK1A1CSNK1E | |
| SCHEMBL6407886 | 0.85 | MDM2 (0.68) | MDM2NPC1CSNK1DCSNK1A1CSNK1E | |
| SCHEMBL7243796 | 0.84 | MDM2 (0.54) | MDM2NPC1CSNK1DCSNK1A1CSNK1E | |
| SCHEMBL6407911 | 0.83 | NPC1 (0.62) | MDM2NPC1CSNK1DCSNK1A1CSNK1E | |
| SCHEMBL6410986 | 0.82 | MDM2 (0.60) | MDM2FLT3ERBB2 | |
| SCHEMBL6403896 | 0.80 | ERBB2 (0.58) | MDM2NPC1CSNK1DCSNK1A1CSNK1E | |
| SCHEMBL6403898 | 0.80 | ERBB2 (0.58) | MDM2NPC1CSNK1DCSNK1A1CSNK1E | |
| SCHEMBL6391514 | 0.77 | MDM2 (0.61) | MDM2NPC1CSNK1DCSNK1A1CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855730-B2 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-6531502-B1 | Antitumor | SUGEN, INC. | 2003-03-11 | — | — | US | disclosed |