Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 9/20 | 0.60 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.50 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.50 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6391805 | 0.93 | MDM2 (0.69) | MDM2CDYL2CDYLCDY1; CDY1BLRRK2 | |
| SCHEMBL6391798 | 0.93 | MDM2 (0.69) | MDM2CDYL2CDYLCDY1; CDY1BLRRK2 | |
| SCHEMBL6407886 | 0.83 | MDM2 (0.68) | MDM2ERBB2FLT3 | |
| SCHEMBL6408722 | 0.82 | MDM2 (0.50) | MDM2ERBB2FLT3 | |
| SCHEMBL7243796 | 0.79 | MDM2 (0.54) | MDM2ERBB2FLT3 | |
| SCHEMBL6407911 | 0.77 | NPC1 (0.62) | MDM2ERBB2FLT3 | |
| SCHEMBL5472567 | 0.76 | MDM2 (1.00) | MDM2CDYL2CDYLCDY1; CDY1BLRRK2 | |
| SCHEMBL14448905 | 0.76 | MDM2 (0.83) | MDM2CDYL2CDYLCDY1; CDY1BLRRK2 | |
| SCHEMBL5472563 | 0.76 | MDM2 (1.00) | MDM2CDYL2CDYLCDY1; CDY1BLRRK2 | |
| SCHEMBL5477633 | 0.76 | MDM2 (0.83) | MDM2CDYL2CDYLCDY1; CDY1BLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855730-B2 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-6531502-B1 | Antitumor | SUGEN, INC. | 2003-03-11 | — | — | US | disclosed |