SCHEMBL6408760

SCHEMBL6408760

Cc1ccc(NC(=O)CC(=O)CCl)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.71
HDAC3 O15379 2/20 0.53
HDAC1 Q13547 2/20 0.53
HDAC2 Q92769 2/20 0.53
HDAC10 Q969S8 2/20 0.53
HDAC11 Q96DB2 2/20 0.53
HDAC8 Q9BY41 2/20 0.53
HDAC6 Q9UBN7 2/20 0.53
HDAC4 P56524 1/20 0.53
HDAC7 Q8WUI4 1/20 0.53
HDAC9 Q9UKV0 1/20 0.53
HDAC5 Q9UQL6 1/20 0.53
TDP1 Q9NUW8 1/20 0.52
ALDH1A1 P00352 2/20 0.51
NCOR2 Q9Y618 1/20 0.51
SMN1; SMN2 Q16637 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
MEN1 O00255 1/20 0.50
HTT P42858 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10617946 0.90 NPC1 (0.57) POLBALDH1A1SMN1; SMN2NPSR1MEN1
SCHEMBL916728 0.86 POLB (0.73) POLBHDAC3HDAC1HDAC2HDAC10
SCHEMBL11170461 0.85 POLB (0.77) POLBHDAC3HDAC1HDAC2HDAC10
SCHEMBL8141144 0.84 POLB (1.00) POLBHDAC3HDAC1HDAC2HDAC10
SCHEMBL14509049 0.83 POLB (0.74) POLBHDAC3HDAC1HDAC2HDAC10
SCHEMBL6408425 0.83 KMT2A (0.57) POLBALDH1A1SMN1; SMN2NPSR1MEN1
SCHEMBL11739018 0.81 GAA (0.58) POLBHDAC3HDAC1HDAC2HDAC6
SCHEMBL6414213 0.81 KMT2A (0.71) POLBTDP1ALDH1A1SMN1; SMN2NPSR1
SCHEMBL6414674 0.81 POLB (0.71) POLBHDAC3HDAC1HDAC2HDAC10
SCHEMBL5364516 0.81 HTT (0.59) POLBHDAC3HDAC1HDAC2HDAC10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6921770-B2 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2005-07-26 US disclosed
EP-1311160-A4 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INST SCI & TECH (KR) 2004-04-21 EP disclosed
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-10-30 US disclosed
EP-1311160-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-05-21 EP disclosed
WO-2002013611-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2002-02-21 WO disclosed
US-4064140-A FROM A CHLOROACETO-ACETANILIDE AND CYANIDE IONS CIBA-GEIGY CORPORATION (US) 1977-12-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same TYR, SYPL1, SSBP1 POLB 2313/4885HDAC3 4884/4885HDAC1 4876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.