Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | DGKA | P23743 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 4/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16898748 | 0.89 | LMNA (0.54) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL27510080 | 0.88 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL4373222 | 0.88 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL28215278 | 0.87 | KDM4E (0.55) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL3975355 | 0.87 | LMNA (0.51) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL26715716 | 0.86 | KDM4E (0.72) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL11350235 | 0.86 | KDM4E (0.72) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL11400551 | 0.86 | LMNA (0.50) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL27654683 | 0.86 | KDM4E (0.71) | KDM4EDUSP3MEN1KMT2ALMNA | |
| SCHEMBL29854252 | 0.85 | KDM4E (0.70) | KDM4EDUSP3MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230390216-A1 | BROMHEXINE FOR THE TREATMENT OF PAIN | KERN KAI UWE (DE) | 2023-12-07 | — | — | US | disclosed |
| EP-3638223-B1 | BROMHEXINE FOR THE TREATMENT OF PAIN | KERN KAI UWE (DE) | 2023-10-25 | — | — | EP | disclosed |
| US-11759439-B2 | Bromhexine for the treatment of pain | KERN KAI UWE (DE) | 2023-09-19 | — | — | US | disclosed |
| US-20200197330-A1 | BROMHEXINE FOR THE TREATMENT OF PAIN | KERN KAI UWE (DE) | 2020-06-25 | — | — | US | disclosed |
| EP-3638223-A1 | BROMHEXINE FOR THE TREATMENT OF PAIN | Kern, Kai-Uwe (DE) | 2020-04-22 | — | — | EP | disclosed |
| WO-2018229119-A1 | BROMHEXINE FOR THE TREATMENT OF PAIN | KERN KAI UWE (DE) | 2018-12-20 | — | — | WO | disclosed |
| EP-3415143-A1 | BROMHEXINE FOR THE TREATMENT OF PAIN | Kern, Kai-Uwe (DE) | 2018-12-19 | — | — | EP | disclosed |
| US-20050266058-A1 | Topical preparations containing ambroxol | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-01 | — | — | US | disclosed |