Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.55 |
| ▸ | CCR5 | P51681 | 4/20 | 0.45 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6409114 | 0.99 | ROCK2 (0.54) | ROCK2ROCK1CCR5UTS2RTSHR | |
| SCHEMBL6409997 | 0.94 | ROCK2 (0.50) | ROCK2ROCK1CCR5UTS2RTSHR | |
| SCHEMBL6418297 | 0.94 | UTS2R (0.49) | ROCK2ROCK1CCR5UTS2RTSHR | |
| Hydrochloric Acid SCHEMBL6415576 | 0.94 | UTS2R (0.48) | ROCK2ROCK1CCR5UTS2RTSHR | |
| Hydrochloric Acid SCHEMBL6415177 | 0.94 | ROCK2 (0.49) | ROCK2ROCK1CCR5UTS2RTSHR | |
| SCHEMBL6415293 | 0.92 | ROCK2 (0.47) | ROCK2ROCK1CCR5UTS2RGHSR | |
| SCHEMBL6412955 | 0.91 | UTS2R (0.53) | ROCK2ROCK1CCR5UTS2RCYP2D6 | |
| Hydrochloric Acid SCHEMBL6416610 | 0.91 | ROCK2 (0.46) | ROCK2ROCK1CCR5UTS2RGHSR | |
| Hydrochloric Acid SCHEMBL6409513 | 0.91 | UTS2R (0.52) | ROCK2ROCK1CCR5UTS2R | |
| SCHEMBL6416612 | 0.91 | ROCK2 (0.47) | ROCK2ROCK1CCR5UTS2RTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | ROCK2 1735/4885ROCK1 1002/4885CCR5 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.