Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409131 | 1.00 | PPARG (0.48) | PPARGNR1H4ALOX5MEN1KMT2A | |
| SCHEMBL6557707 | 0.89 | NR1H4 (0.49) | PPARGNR1H4MEN1KMT2AS1PR4 | |
| SCHEMBL6557711 | 0.89 | NR1H4 (0.49) | PPARGNR1H4MEN1KMT2AS1PR4 | |
| SCHEMBL5726523 | 0.86 | NR1H4 (0.46) | NR1H4ALOX5MEN1KMT2AS1PR4 | |
| SCHEMBL5726521 | 0.86 | NR1H4 (0.46) | NR1H4ALOX5MEN1KMT2AS1PR4 | |
| SCHEMBL5607238 | 0.86 | MAPT (0.41) | PPARGKMT2AMAPTS1PR1L3MBTL1 | |
| SCHEMBL5607242 | 0.86 | MAPT (0.41) | PPARGKMT2AMAPTS1PR1L3MBTL1 | |
| SCHEMBL13916943 | 0.81 | AKR1C3 (0.49) | NR1H4MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL6056037 | 0.81 | AKR1C3 (0.49) | NR1H4MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL6056036 | 0.81 | AKR1C3 (0.49) | NR1H4MEN1KMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939988-B1 | Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S LABORATORIES LIMITED (IN) | 2005-09-06 | — | — | US | claimed |